Konishi I, Kuroda H, Mandai M
Department of Obstetrics and Gynecology, Shinshu University School of Medicine, Matsumoto, Japan.
Oncology. 1999 Oct;57 Suppl 2:45-8. doi: 10.1159/000055274.
An epidemiological correlation between infertility therapy and ovarian cancer development has been reported in 1992; consequently, the possible role of gonadotropins in ovarian carcinogenesis has received much attention. Here, we review the effect of gonadotropins on epithelial ovarian carcinoma and ovarian surface epithelium (OSE), which is the histogenetic origin of carcinomas. Recent studies have demonstrated that gonadotropin receptors are expressed in OSE and in approximately half of the ovarian carcinomas. Gonadotropins have also been reported to stimulate cell proliferation and to inhibit apoptosis in OSE and ovarian cancer cells. These data suggest that gonadotropins play an important role in the development, progression, and/or chemoresistance of ovarian carcinomas. Hormonal therapy against gonadotropins may be applicable for patients with ovarian carcinoma.
1992年有报道称不孕治疗与卵巢癌发生之间存在流行病学关联；因此，促性腺激素在卵巢癌发生中的可能作用受到了广泛关注。在此，我们综述促性腺激素对上皮性卵巢癌和卵巢表面上皮（OSE）的影响，卵巢表面上皮是卵巢癌的组织发生起源。最近的研究表明，促性腺激素受体在OSE和大约一半的卵巢癌中表达。也有报道称促性腺激素可刺激OSE和卵巢癌细胞的细胞增殖并抑制其凋亡。这些数据表明促性腺激素在卵巢癌的发生、发展和/或化疗耐药中起重要作用。针对促性腺激素的激素治疗可能适用于卵巢癌患者。
