Mandai Masaki, Konishi Ikuo, Kuroda Hideki, Fujii Shingo
Department of Gynecology and Obstetrics, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan.
Mol Cell Endocrinol. 2007 Apr 15;269(1-2):61-4. doi: 10.1016/j.mce.2006.11.014. Epub 2007 Feb 6.
A link between infertility therapy, especially ovulation induction therapy using gonadotropins, and the development of ovarian cancer has long been an issue of debate since an epidemiological report supporting the possibility appeared in 1992. A number of clinical/epidemiological and biological studies, including a few that we conducted, have revealed various facts regarding this issue. The aim of this short review was to summarize the last 10 years findings and to address the implications of the debates on this issue.
自1992年一份支持这种可能性的流行病学报告出现以来，不孕治疗，尤其是使用促性腺激素的促排卵治疗与卵巢癌的发生之间的联系一直是一个有争议的问题。包括我们进行的一些研究在内的许多临床/流行病学和生物学研究，都揭示了关于这个问题的各种事实。这篇简短综述的目的是总结过去10年的研究结果，并探讨关于这个问题的争论的意义。
