Department of Gynecology and Obstetrics, Baskent University School of Medicine, Konya Medical and Research Center, Selcuklu, Konya, Turkey.
Department of Gynecologic Oncology, Zekai Tahir Burak Women's Health, Education and Research Hospital, Ankara, Turkey.
J Ovarian Res. 2019 Feb 11;12(1):16. doi: 10.1186/s13048-019-0491-7.
The aim of the present study was to investigate the prognostic significance of preoperative complete blood count inflammatory markers in women operated for invasive Epithelial Ovarian Cancer (EOC).
Two hundred forty four patients that underwent operation with the diagnosis of invasive EOC between 2006 and 2014 were included in the study. The date of operation, date of recurrence and final mortality evaluations were performed for survival analysis. The sensitivity, specificity, PPV and NPV were separately calculated with ROC analysis. Survival analysis was carried out with Kaplan Meier-Log Rank Method.
Five-years overall survival rate was 56, 9% and 5-year disease-free survival (DFS) rate was 45,5%. Advanced disease stage, moderate-poor tumor differentiation, and the presence of recurrence were determined to have significant inverse relation at mean survival and 5-year survival rates. Neutrophil/lymphocyte ratio (NLR) and Platelet lymphocyte ratio (PLR) had prognostic effect on both DFS and overall survival based upon the cut-off values determined in the study (PLR = 231, s36, NLR = 3,83). Histopathological subtypes were not found to have any prognostic value. In correlation analysis, PLR and NLR had positive correlation with each other and negative correlation with overall survival.
Inflammatory markers such as NLR and PLR have independent prognostic value for women who undergo surgery for invasive EOC.
本研究旨在探讨术前全血细胞炎症标志物对接受手术治疗的浸润性卵巢上皮癌（EOC）女性的预后意义。
纳入 2006 年至 2014 年间接受手术治疗浸润性 EOC 的 244 例患者。对生存分析进行手术日期、复发日期和最终死亡率评估。分别用 ROC 分析计算敏感性、特异性、PPV 和 NPV。用 Kaplan-Meier-Log Rank 法进行生存分析。
5 年总生存率为 56.9%，5 年无病生存率（DFS）为 45.5%。晚期疾病分期、中-低肿瘤分化程度和复发的存在被确定为与平均生存和 5 年生存率呈显著负相关。根据本研究确定的截断值，中性粒细胞/淋巴细胞比值（NLR）和血小板/淋巴细胞比值（PLR）对 DFS 和总生存均有预后作用（PLR=231，s36，NLR=3.83）。组织病理学亚型未发现有任何预后价值。在相关性分析中，PLR 和 NLR 相互之间呈正相关，与总生存率呈负相关。
NLR 和 PLR 等炎症标志物对接受手术治疗的浸润性 EOC 女性具有独立的预后价值。
