Effect of glucose on the activity of feeding centres before and after parasagittal cuts between medial and lateral hypothalamus.

Intracarotid administration of isotonic glucose (0.5 ml of 5.4%) in the starving albino rats produced an increase in the multiunit activity (MUA) of ventromedial hypothalamus (satiety centre) and a decrease in the MUA of the lateral hypothalamic area (feeding centre). Intracarotid infusion of normal saline did not change the MUA of any of these centres. Parasagittal knife cuts placed in between the satiety and feeding centres did not affect the responsiveness of these centres to glucose administration as indicated by the recorded multiunit activity.