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[非诺特罗/维拉帕米长期抑制分娩期间的血小板功能(作者译)]

[Platelet function during long term inhibition of labour by fenoterol/verapamil (author's transl)].

作者信息

Briel R C, Kunz S, Kidess E

出版信息

Z Geburtshilfe Perinatol. 1978 Dec;182(6):424-7.

PMID:105482
Abstract

Platelet function has been studied in 22 patients (methods according to Born and Breddin) during tocolysis with long term administration of intravenous Fenoterol/Verapamil. The extend and speed of platelet aggregation, according to the Born test, were constant in the following 12 days except for a small increase on the second day. The phase of disaggregation remained unchanged. The reaction time to collagen was prolonged up to the 3rd-4th day. Spontaneous platelet aggregation showed a tendency to decrease up to day 3--4; thereafter, there was a return to the original values. The present data show that a hemostatic action in platelet function cannot be expected during long term tocolysis. Thus, there is no evidence that Fenoterol acts as an inhibitor of platelet aggregation in pregnancy.

摘要

在22例患者中(采用Born和Breddin的方法),研究了长期静脉输注非诺特罗/维拉帕米进行安胎治疗期间的血小板功能。根据Born试验,除第二天有小幅增加外,血小板聚集的程度和速度在接下来的12天内保持恒定。解聚阶段保持不变。对胶原的反应时间延长至第3 - 4天。自发性血小板聚集在第3 - 4天前呈下降趋势;此后,恢复到原始值。目前的数据表明,长期安胎治疗期间不能预期血小板功能有止血作用。因此,没有证据表明非诺特罗在妊娠期间作为血小板聚集抑制剂起作用。

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