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[长期使用酚妥拉明进行保胎治疗后新生儿的心脏状况(作者译)]

[The cardiac situation of newborn children after long-term tocolysis with fenoterol (author's transl)].

作者信息

Meinen K, Al-Issa H, Brienl H, Schmidt E W

出版信息

Geburtshilfe Frauenheilkd. 1981 Feb;41(2):103-6. doi: 10.1055/s-2008-1036973.

Abstract

516 newborn children were subject to a thorough cardiac and neurological test program after a long-term tocolysis with Fenoterol with and without a supplementary medication of Verapamil. No symptoms of a myocardial damage caused by the drug appeared neither in the electrocardiogram nor by means of lab-chemical parameters such as CK-MB, Serum-Myoglobin and CK-B. Except for premature children, no significant neurological characteristics were found either. Due to the low quantity of Fenoterol passing through the placenta and based on the minimum cumulation of Fenoterol in the fetal tissue, especially in the fetal myocardium, a tocolysis does not seem to have any significantly dangerous fetal effects, if control parameters are strictly adhered to. The endeavoured therapeutical objective, namely the prevention of premature labour, thus justifies the application of the betasympathomimetic Fenoterol.

摘要

516名新生儿在使用间羟舒喘宁进行长期保胎治疗且有或没有维拉帕米辅助用药后,接受了全面的心脏和神经学检查程序。无论是在心电图中,还是通过实验室化学参数如肌酸激酶同工酶(CK-MB)、血清肌红蛋白和肌酸激酶B,均未出现由该药物引起的心肌损伤症状。除早产儿外,也未发现明显的神经学特征。由于间羟舒喘宁通过胎盘的量较少,且基于其在胎儿组织尤其是胎儿心肌中的最低蓄积量,如果严格遵守控制参数,保胎治疗似乎不会对胎儿产生任何明显危险的影响。因此,旨在预防早产的治疗目标证明了使用β-拟交感神经药间羟舒喘宁是合理的。

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