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1
The effect of acetoxycycloheximide on rate of accumulation of cerebral catecholamines from circulating tyrosine as related to its effect on memory.乙酰氧基环己酰亚胺对脑儿茶酚胺从循环酪氨酸积累速率的影响及其与对记忆影响的关系。
Proc Natl Acad Sci U S A. 1975 Feb;72(2):479-82. doi: 10.1073/pnas.72.2.479.
2
Studies on memory: inhibitors of protein synthesis also inhibit catecholamine synthesis.关于记忆的研究：蛋白质合成抑制剂也会抑制儿茶酚胺的合成。
Proc Natl Acad Sci U S A. 1975 Nov;72(11):4660-3. doi: 10.1073/pnas.72.11.4660.
3
Role of tyrosine in the acute effects of ethanol on rat brain catecholamine synthesis.酪氨酸在乙醇对大鼠脑儿茶酚胺合成的急性影响中的作用。
Pharmacol Biochem Behav. 1983;18 Suppl 1:389-96. doi: 10.1016/0091-3057(83)90205-8.
4
Inhibition of the in vivo biosynthesis and changes of catecholamine levels in rat brain after alpha-methyl-p-tyrosine; time- and dose-response relationships.α-甲基对酪氨酸对大鼠脑内儿茶酚胺生物合成的抑制作用及儿茶酚胺水平的变化；时间和剂量反应关系。
Naunyn Schmiedebergs Arch Pharmacol. 1978 Sep;304(2):111-23. doi: 10.1007/BF00495547.
5
Catecholamine concentrations and the activity of tyrosine hydroxylase after an increase in the concentration of tyrosine in rat tissues.大鼠组织中酪氨酸浓度升高后儿茶酚胺浓度及酪氨酸羟化酶活性
Br J Pharmacol. 1972 Feb;44(2):307-10. doi: 10.1111/j.1476-5381.1972.tb07268.x.
6
Neurochemical and behavioral effects of catecholamine and protein synthesis inhibitors in mice.儿茶酚胺与蛋白质合成抑制剂对小鼠的神经化学及行为学影响。
Pharmacol Biochem Behav. 1986 Mar;24(3):631-45. doi: 10.1016/0091-3057(86)90569-1.
7
Lasting biological effects of early environmental influences. 8. Effects of neonatal infection, perinatal malnutrition, and crowding on catecholamine metabolism of brain.早期环境影响的持久生物学效应。8. 新生儿感染、围产期营养不良及拥挤对脑儿茶酚胺代谢的影响。
J Exp Med. 1972 Nov 1;136(5):1031-42. doi: 10.1084/jem.136.5.1031.
8
Effect of concussive head injury on central catecholamine levels and synthesis rates in rat brain regions.震荡性脑损伤对大鼠脑区中枢儿茶酚胺水平及合成率的影响。
J Neurochem. 1979 Jul;33(1):89-95. doi: 10.1111/j.1471-4159.1979.tb11710.x.
9
Effect of scopolamine on the cerebral accumulation of 14 C-catecholamines from 14 C-tyrosine.东莨菪碱对由14C-酪氨酸生成的14C-儿茶酚胺在脑内蓄积的影响。
Pharmacology. 1972;8(4):291-9. doi: 10.1159/000136345.
10
Effects of anisomycin and CNS stimulants on brain catecholamine synthesis.茴香霉素和中枢神经系统兴奋剂对脑儿茶酚胺合成的影响。
Pharmacol Biochem Behav. 1978 Oct;9(4):559-61. doi: 10.1016/0091-3057(78)90059-x.

引用本文的文献

1
Lidocaine attenuates anisomycin-induced amnesia and release of norepinephrine in the amygdala.利多卡因可减轻安非他命诱导的杏仁核去甲肾上腺素释放和记忆障碍。
Neurobiol Learn Mem. 2011 Sep;96(2):136-42. doi: 10.1016/j.nlm.2011.03.007. Epub 2011 Mar 29.
2
The role of protein synthesis in memory consolidation: progress amid decades of debate.蛋白质合成在记忆巩固中的作用：历经数十年争论后的进展。
Neurobiol Learn Mem. 2008 Mar;89(3):293-311. doi: 10.1016/j.nlm.2007.09.010. Epub 2007 Nov 28.
3
Studies on memory: inhibitors of protein synthesis also inhibit catecholamine synthesis.关于记忆的研究：蛋白质合成抑制剂也会抑制儿茶酚胺的合成。
Proc Natl Acad Sci U S A. 1975 Nov;72(11):4660-3. doi: 10.1073/pnas.72.11.4660.
4
The inhibition of protein synthesis by glutarimide antibiotics and long-term memory.戊二酰亚胺类抗生素对蛋白质合成的抑制作用与长期记忆
Ir J Med Sci. 1978 Aug;147 Suppl 1:63-5. doi: 10.1007/BF02947907.
5
The neurochemistry of learning and memory.学习与记忆的神经化学
Environ Health Perspect. 1978 Oct;26:143-7. doi: 10.1289/ehp.7826143.

本文引用的文献

1
A RAPID AND SIMPLE RADIOASSAY FOR TYROSINE HYDROXYLASE ACTIVITY.一种快速简便的酪氨酸羟化酶活性放射测定法。
Anal Biochem. 1964 Sep;9:122-6. doi: 10.1016/0003-2697(64)90092-2.
2
INHIBITION OF THE SYNTHESIS OF PROTEIN IN INTACT ANIMALS BY ACETOXYCYCLOHEXIMIDE AND A METABOLIC DERANGEMENT CONCOMITANT WITH THIS BLOCKADE.乙酰氧基环己酰亚胺对完整动物体内蛋白质合成的抑制作用以及伴随这种阻断的代谢紊乱。
Biochem Pharmacol. 1963 Aug;12:855-65. doi: 10.1016/0006-2952(63)90116-3.
3
A study of the factors affecting the aluminum oxide-trihydroxyindole procedure for the analysis of catecholamines.一项关于影响用于儿茶酚胺分析的氧化铝 - 三羟基吲哚法的因素的研究。
J Pharmacol Exp Ther. 1962 Dec;138:360-75.
4
A fluorometric method for the estimation of tyrosine in plasma and tissues.一种用于估算血浆和组织中酪氨酸的荧光测定法。
J Lab Clin Med. 1957 Nov;50(5):733-6.
5
End-product inhibition of tyrosine hydroxylase as a possible mechanism for regulation of norepinephrine synthesis.酪氨酸羟化酶的终产物抑制作为去甲肾上腺素合成调节的一种可能机制。
Mol Pharmacol. 1967 Nov;3(6):549-55.
6
Memory impairment after subcutaneous injection of acetoxycycloheximide.皮下注射乙酰氧基环己酰亚胺后的记忆损害
Science. 1968 May 3;160(3827):556-7. doi: 10.1126/science.160.3827.556.
7
Tryptophan derivatives as inhibitors of tyrosine hydroxylase in vivo and in vitro.色氨酸衍生物在体内和体外作为酪氨酸羟化酶抑制剂的研究
Mol Pharmacol. 1968 Sep;4(5):445-51.
8
Selective release of newly synthesized norepinephrine from the cat spleen during sympathetic nerve stimulation.交感神经刺激期间猫脾脏中新合成去甲肾上腺素的选择性释放。
J Pharmacol Exp Ther. 1968 Jun;161(2):271-8.
9
Isolation and determination of free endogenous and radioactive tyrosine in studies on catecholamine synthesis in the rat brain.大鼠脑内儿茶酚胺合成研究中游离内源性及放射性酪氨酸的分离与测定
Life Sci. 1968 Apr 15;7(8):387-94. doi: 10.1016/0024-3205(68)90038-6.
10
Effect of acetoxycycloheximide on learning and memory of a light-dark discrimination.乙酰氧基环己酰亚胺对明暗辨别学习与记忆的影响。
Nature. 1968 Apr 20;218(5138):271-3. doi: 10.1038/218271a0.

乙酰氧基环己酰亚胺对脑儿茶酚胺从循环酪氨酸积累速率的影响及其与对记忆影响的关系。

The effect of acetoxycycloheximide on rate of accumulation of cerebral catecholamines from circulating tyrosine as related to its effect on memory.

作者信息

Goodman R H, Flexner J B, Flexner L B

出版信息

Proc Natl Acad Sci U S A. 1975 Feb;72(2):479-82. doi: 10.1073/pnas.72.2.479.

DOI:10.1073/pnas.72.2.479
PMID:1054829
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC432335/
Abstract

The rate of accumulation of newly synthesized catecholamines and endogenous catecholamine levels in mice were determined after an amnestic intracranial dose of acetoxycycloheximide. Rates of accumulation were found to be severly decreased for a period of 12 hr after injection. Total catecholamine levels were increased from 1 to 4 hr, then decreased 17 hr following injection. These results are discussed in terms of previous behavioral observations. It is pointed out that they weaken the assumption that acetoxycycloheximide's amnestic effects are solely due to inhibition of protein synthesis.

摘要

在给予失忆性颅内剂量的乙酰氧基环己酰亚胺后，测定了小鼠中新合成儿茶酚胺的积累速率和内源性儿茶酚胺水平。发现注射后12小时内积累速率严重降低。总儿茶酚胺水平在注射后1至4小时升高，然后在17小时后降低。根据先前的行为观察对这些结果进行了讨论。指出这些结果削弱了乙酰氧基环己酰亚胺的失忆作用仅归因于蛋白质合成抑制的假设。