Goodman R H, Flexner J B, Flexner L B
Proc Natl Acad Sci U S A. 1975 Feb;72(2):479-82. doi: 10.1073/pnas.72.2.479.
The rate of accumulation of newly synthesized catecholamines and endogenous catecholamine levels in mice were determined after an amnestic intracranial dose of acetoxycycloheximide. Rates of accumulation were found to be severly decreased for a period of 12 hr after injection. Total catecholamine levels were increased from 1 to 4 hr, then decreased 17 hr following injection. These results are discussed in terms of previous behavioral observations. It is pointed out that they weaken the assumption that acetoxycycloheximide's amnestic effects are solely due to inhibition of protein synthesis.
在给予失忆性颅内剂量的乙酰氧基环己酰亚胺后,测定了小鼠中新合成儿茶酚胺的积累速率和内源性儿茶酚胺水平。发现注射后12小时内积累速率严重降低。总儿茶酚胺水平在注射后1至4小时升高,然后在17小时后降低。根据先前的行为观察对这些结果进行了讨论。指出这些结果削弱了乙酰氧基环己酰亚胺的失忆作用仅归因于蛋白质合成抑制的假设。