大鼠组织中酪氨酸浓度升高后儿茶酚胺浓度及酪氨酸羟化酶活性
Catecholamine concentrations and the activity of tyrosine hydroxylase after an increase in the concentration of tyrosine in rat tissues.
作者信息
Dairman W
出版信息
Br J Pharmacol. 1972 Feb;44(2):307-10. doi: 10.1111/j.1476-5381.1972.tb07268.x.
Abstract
The concentrations of tyrosine in rat plasma and brain were increased 2-7 fold by the administration of either L-tyrosine or cycloheximide. Under these conditions catecholamine concentrations in the brain and the heart remained unchanged even when the rats were maintained in a cold environment to increase catecholamine turnover. The data are interpreted to mean that an increase in the tyrosine concentration in the tissues does not result in an in vivo substrate inhibition of tyrosine hydroxylase.
摘要
给予L-酪氨酸或环己酰亚胺后，大鼠血浆和脑中酪氨酸的浓度增加了2至7倍。在这些条件下，即使将大鼠置于寒冷环境中以增加儿茶酚胺周转率，脑和心脏中的儿茶酚胺浓度仍保持不变。这些数据被解释为意味着组织中酪氨酸浓度的增加不会导致体内酪氨酸羟化酶的底物抑制。
相似文献
1
Catecholamine concentrations and the activity of tyrosine hydroxylase after an increase in the concentration of tyrosine in rat tissues.大鼠组织中酪氨酸浓度升高后儿茶酚胺浓度及酪氨酸羟化酶活性
Br J Pharmacol. 1972 Feb;44(2):307-10. doi: 10.1111/j.1476-5381.1972.tb07268.x.
2
Effect of oudenone on adrenal tyrosine hydroxylase activity in vivo and on tissue catecholamine concentrations.
Biochem Pharmacol. 1971 Sep;20(9):2505-7. doi: 10.1016/0006-2952(71)90251-6.
3
The effects of repeated D-lysergic acid diethylamide injections on catecholamine levels and tyrosine hydroxylase activity in rat brain regions.
J Neurochem. 1977 Jan;28(1):59-62. doi: 10.1111/j.1471-4159.1977.tb07708.x.
4
Role of tyrosine in the acute effects of ethanol on rat brain catecholamine synthesis.酪氨酸在乙醇对大鼠脑儿茶酚胺合成的急性影响中的作用。
Pharmacol Biochem Behav. 1983;18 Suppl 1:389-96. doi: 10.1016/0091-3057(83)90205-8.
5
Catecholamine levels and tyrosine hydroxylase activities in rat brain regions after chronic treatment with, and withdrawal of, methamphetamine.
Biochem Pharmacol. 1981 Jun 15;30(12):1543-9. doi: 10.1016/0006-2952(81)90379-8.
6
Correlation between tyrosine hydroxylase activity and catecholamine concentration or turnover in brain regions.脑区中酪氨酸羟化酶活性与儿茶酚胺浓度或周转率之间的相关性。
J Neurochem. 1977 Oct;29(4):639-43. doi: 10.1111/j.1471-4159.1977.tb07780.x.
7
Changes in brain catecholamines and spontaneous locomotor activity in response to thyrotropin releasing hormone.响应促甲状腺激素释放激素时脑儿茶酚胺和自发运动活性的变化。
Res Commun Chem Pathol Pharmacol. 1976 Dec;15(4):743-52.
8
9
Carbamazepine decreases catecholamine turnover in the rat brain.卡马西平可降低大鼠脑内儿茶酚胺的周转率。
J Pharmacol Exp Ther. 1984 Oct;231(1):166-72.
10
Influence of liver injury on the catecholamine metabolism in rat brain.肝损伤对大鼠脑内儿茶酚胺代谢的影响。
Acta Med Okayama. 1984 Apr;38(2):93-9. doi: 10.18926/AMO/30334.
引用本文的文献
1
Sympathetic activity is correlated with satellite cell aging and myogenesis via β2-adrenoceptor.交感神经活动通过β2-肾上腺素受体与卫星细胞衰老和肌生成相关。
Stem Cell Res Ther. 2021 Sep 16;12(1):505. doi: 10.1186/s13287-021-02571-8.
2
Dopamine synthesis by non-dopaminergic neurons in the arcuate nucleus of rat fetuses.大鼠胎儿弓状核中非多巴胺能神经元的多巴胺合成
Neurosci Behav Physiol. 2005 Oct;35(8):809-13. doi: 10.1007/s11055-005-0129-7.
3
Cycloheximide and acetoxycycloheximide: inhibition of tyrosine hydroxylase activity and amnestic effects.放线菌酮和乙酰氧基放线菌酮：对酪氨酸羟化酶活性的抑制作用及遗忘效应。
Proc Natl Acad Sci U S A. 1973 Feb;70(2):354-6. doi: 10.1073/pnas.70.2.354.
4
Studies on memory: inhibitors of protein synthesis also inhibit catecholamine synthesis.关于记忆的研究：蛋白质合成抑制剂也会抑制儿茶酚胺的合成。
Proc Natl Acad Sci U S A. 1975 Nov;72(11):4660-3. doi: 10.1073/pnas.72.11.4660.
5
d-Tyrosine prevents hypertension in DOCA-saline treated uninephrectomised rats.d-酪氨酸可预防去氧皮质酮-生理盐水处理的单侧肾切除大鼠的高血压。
Pflugers Arch. 1979 Apr 30;379(3):245-50. doi: 10.1007/BF00581428.
本文引用的文献
1
ELUCIDATION OF THE RATE-LIMITING STEP IN NOREPINEPHRINE BIOSYNTHESIS IN THE PERFUSED GUINEA-PIG HEART.灌注豚鼠心脏中去甲肾上腺素生物合成限速步骤的阐明
J Pharmacol Exp Ther. 1965 Apr;148:1-8.
2
BLOCKADE OF ENDOGENOUS NOREPINEPHRINE SYNTHESIS BY ALPHA-METHYL-TYROSINE, AN INHIBITOR OF TYROSINE HYDROXYLASE.酪氨酸羟化酶抑制剂α-甲基酪氨酸对内源性去甲肾上腺素合成的阻断作用
J Pharmacol Exp Ther. 1965 Jan;147:86-95.
3
The differential determination of catecholamines in urine.尿中儿茶酚胺的鉴别测定
Can J Biochem Physiol. 1959 Oct;37:1153-9.
4
Uptake of tyrosine by rat brain in vivo.大鼠脑在体内对酪氨酸的摄取。
J Biol Chem. 1960 Jul;235:2075-9.
5
A fluorometric method for the estimation of tyrosine in plasma and tissues.一种用于估算血浆和组织中酪氨酸的荧光测定法。
J Lab Clin Med. 1957 Nov;50(5):733-6.
6
End-product inhibition of tyrosine hydroxylase as a possible mechanism for regulation of norepinephrine synthesis.酪氨酸羟化酶的终产物抑制作为去甲肾上腺素合成调节的一种可能机制。
Mol Pharmacol. 1967 Nov;3(6):549-55.
7
Acceleration of norepinephrine synthesis in the rat submaxillary gland in vivo during sympathetic nerve stimulation.交感神经刺激期间大鼠颌下腺去甲肾上腺素合成在体内的加速。
Life Sci. 1967 Jan 1;6(1):45-51. doi: 10.1016/0024-3205(67)90360-8.
8
Increased synthesis of norepinephrine and epinephrine in the intact rat during exercise and exposure to cold.在完整大鼠运动及暴露于寒冷环境期间，去甲肾上腺素和肾上腺素的合成增加。
J Pharmacol Exp Ther. 1966 Sep;153(3):440-7.
9
Acceleration of noradrenaline turnover in the mouse heart by cold exposure.寒冷暴露加速小鼠心脏中去甲肾上腺素的周转。
Life Sci. 1965 Dec;4(23):2339-43. doi: 10.1016/0024-3205(65)90258-4.
10
Increase in tyrosine hydroxylase activity after reserpine administration.利血平给药后酪氨酸羟化酶活性增加。
J Pharmacol Exp Ther. 1969 Sep;169(1):74-9.
Zotero 插件