作为腺苷酸环化酶活性调节剂的吗啡受体。
Morphine receptors as regulators of adenylate cyclase activity.
作者信息
Sharma S K, Nirenberg M, Klee W A
出版信息
Proc Natl Acad Sci U S A. 1975 Feb;72(2):590-4. doi: 10.1073/pnas.72.2.590.
Abstract
Morphine inhibits adenylate cyclase (EC 4.6.1.1) activity of neuroblastoma times glioma hybrid cells. The inhibition is stereospecific and is reversed by the antagonist, naloxone. The relative affinities of narcotics for the opiate receptor agree well with their effectiveness as inhibitors of adenylate cyclase. Morphine-sensitive and -insensitive cell lines were found, and the degree of sensitivity was shown to be dependent upon the abundance of narcotic receptors. Thus, morphine receptors are functionally coupled to adenylate cyclase. A molecular mechanism for narcotic addiction and tolerance is proposed.
摘要
吗啡可抑制神经母细胞瘤与胶质瘤杂交细胞的腺苷酸环化酶（EC 4.6.1.1）活性。这种抑制具有立体特异性，且可被拮抗剂纳洛酮逆转。麻醉药对阿片受体的相对亲和力与其作为腺苷酸环化酶抑制剂的效力高度吻合。发现了对吗啡敏感和不敏感的细胞系，且敏感性程度显示取决于阿片受体的丰度。因此，吗啡受体在功能上与腺苷酸环化酶相偶联。本文提出了一种麻醉药成瘾和耐受性的分子机制。
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The glucagon-sensitive adenyl cyclase system in plasma membranes of rat liver. I. Properties.大鼠肝脏质膜中对胰高血糖素敏感的腺苷酸环化酶系统。I. 特性。
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