Chambers R A, Druss B G
Department of Psychiatry, Yale University School of Medicine, New Haven, Conn., USA.
J Clin Psychiatry. 1999 Oct;60(10):664-7.
As admission criteria to inpatient units become more focused on patient safety and behavioral instability, primary treatment often requires use of medications that need to be quick, safe, and effective for control of agitation. This article reviews the evidence that droperidol may serve as the optimal medication for this task.
A comprehensive MEDLINE search of English-language literature was conducted using the search term droperidol concerning the use of droperidol in psychiatric emergencies. Cross-referencing of those articles was conducted to include pertinent articles in the non-psychiatric and European literature regarding safety and early development of the drug.
As evidenced in the animal and clinical literature, studies demonstrate the efficacy and rapidity of onset of droperidol and its relative safety compared with the most widely used antiagitation drug, haloperidol. Evidence for this use of droperidol is particularly compelling for situations in which intramuscular administration is necessary.
Droperidol, while not in widespread use, may prove to be the superior typical neuroleptic for psychiatric emergencies. Increased clinical utilization and study of droperidol for this use is warranted.
随着住院部的收治标准越来越注重患者安全和行为不稳定情况，主要治疗常常需要使用起效迅速、安全且有效的药物来控制激越症状。本文回顾了有关氟哌利多可能是完成这项任务的最佳药物的证据。
使用搜索词“氟哌利多”对英文文献进行了全面的MEDLINE检索，内容涉及氟哌利多在精神科急诊中的应用。对这些文章进行了交叉引用，以纳入非精神科和欧洲文献中有关该药物安全性和早期研发的相关文章。
动物和临床文献表明，与使用最广泛的抗激越药物氟哌啶醇相比，研究证实了氟哌利多的疗效、起效迅速以及相对安全性。对于需要肌内注射的情况，氟哌利多这种用法的证据尤其令人信服。
氟哌利多虽未广泛使用，但可能被证明是精神科急诊中更优的典型抗精神病药物。有必要增加氟哌利多在此用途上的临床应用和研究。
