Crenshaw K L, Peterson M E, Heeb L A, Moroff S D, Nichols R
Rogosin Institute, New York, NY, USA.
J Vet Intern Med. 1996 Nov-Dec;10(6):360-4. doi: 10.1111/j.1939-1676.1996.tb02081.x.
The purpose of this study was to evaluate fructosamine concentrations in clinically healthy cats, sick cats with stress hyperglycemia, and untreated diabetic cats to determine the usefulness of this test in diagnosing diabetes mellitus in cats, and in differentiating the disease from stress-induced hyperglycemia. In addition, we evaluated if the degree of glycemic control in cats treated for diabetes influenced their serum fructosamine concentrations. In the 14 sick cats with stress hyperglycemia, the median serum fructosamine concentration (269 mumol/L) was not significantly different from the median value in the 26 clinically normal cats (252 mumol/L). Two of the 14 cats with stress hyperglycemia (14.3%) had serum fructosamine concentrations above the upper limit of the reference range (175 to 400 mumol/L); on the basis of these results, the test specificity was calculated as 0.86. In 30 cats with untreated diabetes mellitus, the median serum fructosamine concentration was 624 mumol/L, markedly higher than the value in either the normal cats or the cats with stress hyperglycemia. All but 2 of the 30 untreated diabetic cats (6.7%) had serum fructosamine concentration above the upper limit of the reference range; on the basis of these results, the sensitivity of serum fructosamine concentration as a diagnostic test for diabetes mellitus was 0.93. When 30 diabetic cats receiving treatment were divided into 3 groups according to their response to treatment (i.e., poor, fair, and good), the 16 cats that had a good response to treatment had significantly lower serum concentrations of both glucose and fructosamine compared with cats that had either a fair or poor response to treatment. A significant correlation (rs = .70, n = 100, P < .001) was found between serum concentrations of glucose and fructosamine. Results of this study indicate that quantification of serum fructosamine concentration is a meaningful test for the diagnosis of diabetes, for differentiating diabetes from stress hyperglycemia; and for monitoring the metabolic control in treated diabetic cats.
本研究的目的是评估临床健康猫、患有应激性高血糖的病猫以及未经治疗的糖尿病猫的果糖胺浓度，以确定该检测在诊断猫糖尿病以及将该疾病与应激性高血糖相鉴别方面的实用性。此外，我们还评估了糖尿病治疗猫的血糖控制程度是否会影响其血清果糖胺浓度。在14只患有应激性高血糖的病猫中，血清果糖胺浓度中位数（269μmol/L）与26只临床正常猫的中位数（252μmol/L）无显著差异。14只患有应激性高血糖的猫中有2只（14.3%）血清果糖胺浓度高于参考范围上限（175至400μmol/L）；基于这些结果，该检测的特异性计算为0.86。在30只未经治疗的糖尿病猫中，血清果糖胺浓度中位数为624μmol/L，明显高于正常猫或患有应激性高血糖的猫的值。30只未经治疗的糖尿病猫中除2只（6.7%）外，其余所有猫的血清果糖胺浓度均高于参考范围上限；基于这些结果，血清果糖胺浓度作为糖尿病诊断检测的敏感性为0.93。当30只接受治疗的糖尿病猫根据其治疗反应分为3组（即差、一般和好）时，与治疗反应一般或差的猫相比，治疗反应良好的16只猫的血清葡萄糖和果糖胺浓度显著更低。血清葡萄糖和果糖胺浓度之间存在显著相关性（rs = 0.70，n = 100，P < 0.001）。本研究结果表明，血清果糖胺浓度定量检测对于糖尿病诊断、区分糖尿病与应激性高血糖以及监测糖尿病治疗猫的代谢控制是一项有意义的检测。
