粗毛薇甘菊（菊科）成分的研究。

Studies on the constituents of Mikania hirsutissima (Compositae).

作者信息

Ohkoshi E, Makino M, Fujimoto Y

机构信息

College of Pharmacy, Nihon University, Chiba, Japan.

出版信息

Chem Pharm Bull (Tokyo). 1999 Oct;47(10):1436-8. doi: 10.1248/cpb.47.1436.

DOI:10.1248/cpb.47.1436

PMID:10553640

Abstract

Two novel norhumulene-type sesquiterpenes, named mikaniahumulene I (1) and II (2) were isolated along with nine known compounds, seven kaurenic acid-type diterpenes (3-9), a coumarin (10) and a flavone (11), from the aerial parts of Mikania hirsutissima DC (Compositae). The structures of new norhumulenes were determined by spectroscopic means. The cytotoxic activities of isolated compounds against leukemia cells (L 1210) were investigated; among the isolated compounds, 1, 5, 8, and 11 showed relatively strong cytotoxicity.

摘要

从糙毛薇甘菊（菊科）地上部分分离得到两种新型降葎草烯型倍半萜，分别命名为薇甘菊降葎草烯Ⅰ（1）和Ⅱ（2），同时还得到9种已知化合物，包括7种贝壳杉酸型二萜（3 - 9）、1种香豆素（10）和1种黄酮（11）。通过光谱手段确定了新降葎草烯的结构。研究了分离得到的化合物对白血病细胞（L 1210）的细胞毒活性；在分离得到的化合物中，1、5、8和11表现出相对较强的细胞毒性。