Li Chuang-Jun, Zhang Dong-Ming, Luo Yong-Ming, Yu Shi-Shan, Li Yan, Lu Yang
Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, PR China.
Phytochemistry. 2008 Nov;69(16):2867-74. doi: 10.1016/j.phytochem.2008.08.022. Epub 2008 Oct 15.
Bis-sesquiterpenes, henriols A (1), B (2), C (3), and D (4), and three diterpenes, henrilabdanes A (5), B (6), and C (7), together with two known bis-sesquiterpenes and three known labdane diterpenes, were isolated from the ethanol extract of the roots of Chloranthus henryi. Their structures and absolute configurations were elucidated by NMR spectroscopic, X-ray crystallographic and CD analyses. Compounds 1, 5, 6 and 7 showed moderate hepatoprotective activities with IC(50) values of 0.19, 0.66, 0.09 and 0.18 microM, respectively. They were not studied further due to the weak effects noted. Compounds 3 and 8 exhibited cytotoxic activities against three types of cancer cell lines including the hepatoma (BEL-7402), human gastric carcinoma (BGC-823), and colon cancer (HCT-8).
从长叶金粟兰根的乙醇提取物中分离得到了双倍半萜类化合物亨利醇A（1）、B（2）、C（3）和D（4），以及三种二萜类化合物亨利拉丹烷A（5）、B（6）和C（7），还有两种已知的双倍半萜和三种已知的拉丹烷二萜。通过核磁共振光谱、X射线晶体学和圆二色光谱分析确定了它们的结构和绝对构型。化合物1、5、6和7表现出中等程度的肝保护活性，IC50值分别为0.19、0.66、0.09和0.18微摩尔。由于观察到的效果较弱，未对它们进行进一步研究。化合物3和8对三种癌细胞系具有细胞毒性活性，包括肝癌（BEL-7402）、人胃癌（BGC-823）和结肠癌（HCT-8）。
