Delgado G, Tejeda V, Salas A, Chávez M I, Guzmán S, Bolaños A, Aguilar M I, Navarro V, Villarreal M L
Instituto de Química, Universidad Nacional Autónoma de México, Ciudad Universitaria, Circuito Exterior, Coyoacán 04510, Mexico.
J Nat Prod. 1998 Sep;61(9):1082-5. doi: 10.1021/np970548s.
The novel melampolides (11R)-11,13-dihydro-schkuhriolide (7), (11S)-11,13-dihydro-schkuhriolide (8), and schkuhrioidiol (11), along with the known constituents, frutescin (1), schkuhriolide (2), frutescinic acid (4), allo-schkuhriolide (5), and epoxyschkuhriolide (6) were isolated from the aerial parts of Schkuhria schkuhrioides. The structures of the new compounds were determined by spectroscopic methods. Compounds 1, 2, 4, 5, and 6 displayed no significant cytotoxic or antimicrobial activities.
从Schkuhria schkuhrioides的地上部分分离出了新型的蜜茱萸内酯（11R）-11,13-二氢-施库胡里内酯（7）、（11S）-11,13-二氢-施库胡里内酯（8）和施库胡里奥二醇（11），以及已知成分吴茱萸次碱（1）、施库胡里内酯（2）、吴茱萸次碱酸（4）、别-施库胡里内酯（5）和环氧施库胡里内酯（6）。通过光谱方法确定了新化合物的结构。化合物1、2、4、5和6没有显示出显著的细胞毒性或抗菌活性。
