AKR小鼠自发性白血病中15号染色体三体性
Trisomy of chromosome 15 in spontaneous leukemia of AKR mice.
作者信息
Dofuku R, Biedler J L, Spengler B A, Old L J
出版信息
Proc Natl Acad Sci U S A. 1975 Apr;72(4):1515-7. doi: 10.1073/pnas.72.4.1515.
Abstract
Karyotypes of spontaneous thymomas of AKR mice were determined by trypsin-Giemsa banding methods. Trisomy of chromosome 15 occurred in 10 of 11 leukemic mice. Seven of the thymomas were predominantly trisomic for chromosome 15, one was trisomic for chromosome 12, and one exhibited multiple trisomies of chromosomes 3, 12, 15, and 17. Trisomy was not found in the norm-l AKR tissues examined.
摘要
采用胰蛋白酶 - 吉姆萨显带法测定了AKR小鼠自发性胸腺瘤的核型。11只白血病小鼠中有10只出现了15号染色体三体。其中7个胸腺瘤主要是15号染色体三体，1个是12号染色体三体，1个表现出3号、12号、15号和17号染色体的多重三体。在所检测的正常AKR组织中未发现三体现象。
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