Sato Y, Nishimaki T, Date K, Shirai Y, Kurosaki I, Saito Y, Watanabe T, Hatakeyama K
First Department of Surgery, Niigata University School of Medicine, 1-757 Asahimachi-dori, Niigata, Niigata 951-8051, Japan.
Surg Today. 1999;29(10):1075-8. doi: 10.1007/s005950050647.
We present herein the case of a 68-year-old man in whom metachronous liver metastasis from an alpha-fetoprotein (AFP)-producing gastric cancer was successfully treated. The patient initially underwent a distal gastrectomy for an AFP-producing gastric cancer on January 30, 1997, following which the serum AFP level which had been 228 ng/ml prior to surgery decreased to 30 ng/ml. However, 7 months after surgery, follow-up examination revealed an abnormal elevation of the serum AFP level up to 301 ng/ml, and a liver tumor was subsequently detected at segment 8 (S8) by abdominal ultra-sonography. There was no evidence of hepatitis B or C virus infections. After various investigations, he was diagnosed to have liver metastases in S6 and S8, from the AFP-producing gastric cancer, and a partial hepatectomy of S6 and S8 was performed. His postoperative course was uneventful and he was discharged on postoperative day 26. Thereafter, his serum AFP levels decreased and have remained within normal limits for 12 months since his operation. To the best of our knowledge, this is the first case of successful resection of metachronous liver metastasis from an AFP-producing gastric cancer.
我们在此报告一例68岁男性患者，其发生了来自产甲胎蛋白（AFP）胃癌的异时性肝转移，并成功接受了治疗。该患者最初于1997年1月30日因产AFP胃癌接受了远端胃切除术，术前血清AFP水平为228 ng/ml，术后降至30 ng/ml。然而，术后7个月，随访检查发现血清AFP水平异常升高至301 ng/ml，随后通过腹部超声在肝8段（S8）检测到肝肿瘤。没有乙肝或丙肝病毒感染的证据。经过各种检查，他被诊断为产AFP胃癌发生了S6和S8肝转移，并进行了S6和S8部分肝切除术。他的术后病程顺利，术后第26天出院。此后，他的血清AFP水平下降，自手术以来12个月一直保持在正常范围内。据我们所知，这是首例成功切除产AFP胃癌异时性肝转移的病例。
