Enikolopov G, Banerji J, Kuzin B
Cold Spring Harbor Laboratory Cold Spring Harbor, NY 11724, USA.
Cell Death Differ. 1999 Oct;6(10):956-63. doi: 10.1038/sj.cdd.4400577.
Mechanisms controlling the transition of precursor cells from proliferation to differentiation during organism development determine the distinct anatomical features of tissues and organs. NO may mediate such a transition since it can suppress DNA synthesis and cell proliferation. Inhibition of NOS activity in the imaginal discs of Drosophila larvae results in hypertrophy of tissues and organs of the adult fly, whereas ectopic overexpression of NOS has the reciprocal, hypotrophic, effect. Furthermore, NO production is crucial for the establishment of ordered neuronal connections in the visual system of the fly, indicating that NO affects the acquisition of the differentiated phenotype by the neural tissue. Increasing evidence points to a broad role that NO may play in animal development by acting as an essential negative regulator of precursor cell proliferation during tissue and organ morphogenesis.
在生物体发育过程中，控制前体细胞从增殖向分化转变的机制决定了组织和器官独特的解剖学特征。一氧化氮（NO）可能介导这种转变，因为它可以抑制DNA合成和细胞增殖。抑制果蝇幼虫成虫盘的一氧化氮合酶（NOS）活性会导致成年果蝇的组织和器官肥大，而NOS的异位过表达则会产生相反的、组织器官萎缩的效果。此外，NO的产生对于果蝇视觉系统中有序神经连接的建立至关重要，这表明NO会影响神经组织分化表型的获得。越来越多的证据表明，NO可能在动物发育中发挥广泛作用，即在组织和器官形态发生过程中作为前体细胞增殖的重要负调节因子。
