van Praag H, Christie B R, Sejnowski T J, Gage F H
Laboratory of Genetics, Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
Proc Natl Acad Sci U S A. 1999 Nov 9;96(23):13427-31. doi: 10.1073/pnas.96.23.13427.
Running increases neurogenesis in the dentate gyrus of the hippocampus, a brain structure that is important for memory function. Consequently, spatial learning and long-term potentiation (LTP) were tested in groups of mice housed either with a running wheel (runners) or under standard conditions (controls). Mice were injected with bromodeoxyuridine to label dividing cells and trained in the Morris water maze. LTP was studied in the dentate gyrus and area CA1 in hippocampal slices from these mice. Running improved water maze performance, increased bromodeoxyuridine-positive cell numbers, and selectively enhanced dentate gyrus LTP. Our results indicate that physical activity can regulate hippocampal neurogenesis, synaptic plasticity, and learning.
跑步可增加海马齿状回中的神经发生，海马是对记忆功能很重要的脑结构。因此，对两组小鼠进行了空间学习和长时程增强（LTP）测试，一组小鼠饲养在有跑步轮的环境中（跑步组），另一组处于标准条件下（对照组）。给小鼠注射溴脱氧尿苷以标记分裂细胞，并在莫里斯水迷宫中进行训练。对这些小鼠海马切片中的齿状回和CA1区进行LTP研究。跑步改善了水迷宫表现，增加了溴脱氧尿苷阳性细胞数量，并选择性增强了齿状回LTP。我们的结果表明，身体活动可调节海马神经发生、突触可塑性和学习。
