伐昔洛韦治疗眼部带状疱疹：新适应症。一份空白的临床评估文件。
Valaciclovir in herpes zoster ophthalmicus: new indication. An empty clinical assessment file.
出版信息
Prescrire Int. 1999 Jun;8(41):75-6.
PMID:10558445
Abstract
(1) Valaciclovir, a metabolic precursor of aciclovir, improves the bioavailability of the active compound. It is licensed for the prevention of ocular complications of herpes zoster ophthalmicus in immunocompetent subjects. (2) The clinical file on valaciclovir in this indication is very thin. Only two (uninterpretable) trials have been done, both versus aciclovir. Note that oral aciclovir has also been assessed inadequately in this indication. (3) Over 10% of patients treated with valaciclovir in the two trials had nausea or headache.
摘要
(1) 伐昔洛韦是阿昔洛韦的代谢前体，可提高活性化合物的生物利用度。它被批准用于预防免疫功能正常的受试者眼部带状疱疹并发症。(2) 伐昔洛韦在该适应症方面的临床资料非常有限。仅进行了两项（无法解读）试验，均与阿昔洛韦对比。请注意，口服阿昔洛韦在该适应症方面的评估也不充分。(3) 在两项试验中，接受伐昔洛韦治疗的患者中有超过10%出现恶心或头痛。
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