Kishi H, Nishii S, Ono T, Yamaji A, Kasahara N, Hiraoka E, Okada A, Itakura T, Takagi Y
Am J Clin Nutr. 1979 Feb;32(2):332-8. doi: 10.1093/ajcn/32.2.332.
Studies were undertaken to determine rational dosages of vitamin B1 and B6 during long-term intravenous hyperalimentation, using more sensitive techniques than formerly used to evaluate B1 and B6 status. A standard vitamin combination, type A, (usually commercially available products) has been used up to now because of convenience, disregarding the effects of long-term administration. This combination lacks biotin, folic acid, and vitamin E and contains from 10 to 100 times the dietary allowances of such vitamins as B1, B2, B6, B12, and C. In response to the possibility of vitamin overdose, two new vitamin combinations, type B (from commercial products) and type C (a convenient and easily administered combination produced at the hospital) were developed in order to provide the normal dietary allowances and at the same time eliminate any harmful side-effects. From the results obtained, 5 mg/day for thiamin HCl and 3 mg/day for pyridoxine HCl in type B and type C were found to be a sufficient and safe level as opposed to 55 mg/day for thiamin HCl and 102 mg/day for pyridoxine HCl in type A.
开展了多项研究，以确定长期静脉高营养期间维生素B1和B6的合理剂量，所采用的技术比以前用于评估B1和B6状态的技术更为灵敏。由于方便，一种标准的维生素组合（A类，通常为市售产品）迄今一直被使用，而未考虑长期给药的影响。这种组合缺乏生物素、叶酸和维生素E，且所含的维生素B1、B2、B6、B12和C是膳食推荐量的10至100倍。为应对维生素过量的可能性，开发了两种新的维生素组合，B类（市售产品）和C类（医院生产的一种方便且易于给药的组合），以便提供正常的膳食推荐量，同时消除任何有害的副作用。从所得结果来看，发现B类和C类中盐酸硫胺素5毫克/天和盐酸吡哆醇3毫克/天是足够且安全的水平，而A类中盐酸硫胺素为55毫克/天，盐酸吡哆醇为102毫克/天。
