Howard L, Bigaouette J, Chu R, Krenzer B E, Smith D, Tenny C
Am J Clin Nutr. 1983 Mar;37(3):421-8. doi: 10.1093/ajcn/37.3.421.
Ascorbic acid, thiamin, niacin, pyridoxine, and folic acid status was evaluated in eight physiologically stable home parenteral nutrition patients. Six of these subjects received these vitamins as a twice weekly bolus and were studied over a period of 6 days. All vitamin levels were normal except for blood thiamin which was low, 72 h after each bolus. Since transketolase levels remained normal, this fall in blood thiamin probably had no functional significance. The urine excretion pattern of niacin and pyridoxine indicated normal metabolism and retention of these vitamins. Two patients, who required only parenteral fluid and electrolytes to remain weight stable, received none of these vitamins parenterally, but also maintained adequate vitamin status. These results suggest that in long term home parenteral nutrition patients these five vitamins can safely be given twice weekly, rather than daily, and that short bowel patients who maintain their weight without intravenous calories and protein also assimilate adequate amounts of these proximally absorbed water soluble vitamins from their diet.
对8名生理状态稳定的家庭肠外营养患者的抗坏血酸、硫胺素、烟酸、吡哆醇和叶酸状态进行了评估。其中6名受试者每周两次大剂量接受这些维生素，并在6天的时间内进行研究。除每次大剂量给药72小时后血液硫胺素水平较低外，所有维生素水平均正常。由于转酮醇酶水平保持正常，血液中硫胺素的这种下降可能没有功能意义。烟酸和吡哆醇的尿排泄模式表明这些维生素的代谢和保留正常。两名仅需要肠外液体和电解质来维持体重稳定的患者未接受任何肠外维生素，但也维持了足够的维生素状态。这些结果表明，对于长期家庭肠外营养患者，这五种维生素可以安全地每周给药两次，而不是每天给药，并且那些不通过静脉摄入热量和蛋白质就能维持体重的短肠患者也能从饮食中吸收足够量的这些近端吸收的水溶性维生素。
