Choi Y J, Yeh G, Reiner L, Spielvogel A
Am J Clin Pathol. 1979 Jan;71(1):121-4. doi: 10.1093/ajcp/71.1.121.
Immunoblastic sarcoma has been observed in association with, or subsequent to, chronic immune stimulation, connective tissue disorders, and immunoblastic lymphadenopathy. A case of Waldenström's macroglobulinemia progressinng after a few years into immunoblastic sarcoma is reported. Splenectomy led to disappearance of hemolytic anemia and of pulmonary infiltrates, as well as to marked reduction of macroglobulins. Although immunoblastic sarcoma usually terminates fatally within two or three months, complete remission was induced by combination chemotherapy. It is speculated that Waldenström's macroglobulinemia, immunoblastic lymphadenopathy, and immunoblastic sarcoma are related disorders reflecting a clonal nature of immunoblastic lymphoma cells and the plasmacytic cells.
免疫母细胞肉瘤已被观察到与慢性免疫刺激、结缔组织疾病和免疫母细胞性淋巴结病相关或继发于这些疾病之后。本文报告了一例华氏巨球蛋白血症患者，数年后进展为免疫母细胞肉瘤。脾切除术后，溶血性贫血和肺部浸润消失，巨球蛋白水平也显著降低。尽管免疫母细胞肉瘤通常在两三个月内致命，但联合化疗诱导了完全缓解。据推测，华氏巨球蛋白血症、免疫母细胞性淋巴结病和免疫母细胞肉瘤是相关疾病，反映了免疫母细胞淋巴瘤细胞和浆细胞的克隆性质。
