Emmerich B, Pemsl M, Wüst I, Berdel W E, Lechner S, Thiel E, Georgii A, Gössner W, Rastetter J
Blut. 1983 Feb;46(2):81-4. doi: 10.1007/BF00320662.
A case involving a 67 year old man with an immunocytoma initially presenting as Waldenström's macroglobulinemia which transformed into a high grade malignant lymphoma of immunoblastic type after treatment with cyclophosphamide and corticosteroids over 5 months is presented. IgM (kappa) present in the serum in the phase of immunocytoma was demonstrated also on the less differentiated cells of the high grade lymphoma. The permanent production of the same immunoglobulin molecule suggests that both morphologically different malignancies derived from one B cell clone.
本文报告一例67岁男性免疫细胞瘤患者，最初表现为华氏巨球蛋白血症，在接受环磷酰胺和皮质类固醇治疗5个月后转变为免疫母细胞型高级别恶性淋巴瘤。免疫细胞瘤阶段血清中存在的IgM（κ）在高级别淋巴瘤分化较差的细胞上也得到证实。同一免疫球蛋白分子的持续产生表明，这两种形态不同的恶性肿瘤源自同一个B细胞克隆。
