Abe M, Takahashi K, Mori N, Kojima M
Cancer. 1982 Jun 15;49(12):2580-6. doi: 10.1002/1097-0142(19820615)49:12<2580::aid-cncr2820491228>3.0.co;2-5.
An autopsy case of 69-year-old man with Waldenström's macroglobulinemia terminating in immunoblastic sarcoma is reported. In the course of this case, the appearance of plasmocytoid lymphocytes was initially observed in peripheral blood smears and bone marrow punctures, but lymph node biopsy and bone marrow aspirations performed in the terminal stage, as well as autopsy, revealed a diffuse monotonous proliferation of immunoblasts in the lymphoreticular tissues. With the immunofluorescence method and PAP method of Taylor,11 IgM kappa type of immunoglobulin was demonstrated in the cytoplasm of the proliferating cells, and the electron microscopic enzyme-labeled antibody technique identified localization of the immunoglobulin in the nuclear envelope and rough endoplasmic reticula of the immunoblasts. The results indicate that the initial appearance of plasmocytoid lymphocytes in this case and its terminal transformation into immunoblastic sarcoma are rare phenomena occurring in a single clone proliferation disorder of B-cell synthesizing IGM kappa immunoglobulins.
报告了一例69岁患有华氏巨球蛋白血症并最终发展为免疫母细胞肉瘤的男性尸检病例。在该病例过程中，最初在外周血涂片和骨髓穿刺中观察到浆细胞样淋巴细胞的出现，但在末期进行的淋巴结活检和骨髓穿刺以及尸检显示，淋巴网状组织中存在免疫母细胞的弥漫性单一性增殖。采用泰勒的免疫荧光法和PAP法，在增殖细胞的细胞质中证实了IgM κ型免疫球蛋白，并且电子显微镜酶标抗体技术确定了免疫球蛋白在免疫母细胞的核膜和粗面内质网中的定位。结果表明，该病例中浆细胞样淋巴细胞的最初出现及其最终转变为免疫母细胞肉瘤是B细胞合成IGM κ免疫球蛋白的单克隆增殖性疾病中发生的罕见现象。
