Okada M, Sakano T, Senna K, Maruyama T, Murofushi J, Okonogi H, Sato S
Zen-noh Institute of Animal Health, Chiba, Japan.
J Vet Med Sci. 1999 Oct;61(10):1131-5. doi: 10.1292/jvms.61.1131.
An inactivated vaccine prepared from broth culture supernatant of Mycoplasma hyopneumoniae with an aluminum adjuvant was evaluated in three herds (herd A: specific pathogen-free herd, herd B: high health status herd with no clinical signs of respiratory infection, herd C: low health status herd with serious epidemiological and economical problems). A total of 212 pigs from the three herds were divided into two groups. One group was injected twice with the vaccine at 4-week intervals and the other was a control group. No adverse reactions were noted following the vaccinations either systematically or locally in any of the vaccinated pigs from any of the herds. In herd A, the vaccination provided antibody response within 4 weeks after the second vaccination and antibody responses continued for more than 12 weeks. In herds B and C, the number of pigs with lung lesions, mean percentage of lung lesions, and the numbers of M. hyopneumoniae recovered from pigs at slaughter in the vaccinated group were significantly (P < 0.05) reduced compared to the control group. Furthermore, vaccination resulted in improved average daily weight gain (ADG), improved feed conversion ratio (FCR), and improved days to market weight in herd C, whereas no difference in growth performance was shown in herd B. It is suggested that the inactivated vaccine prepared from broth culture supernatant of M. hyopneumoniae is effective in reducing clinical signs and lung lesions. Also, vaccination resulted in improved growth performance in herds where clinical signs and economic losses were significant.
对一种由猪肺炎支原体肉汤培养上清液制备并添加铝佐剂的灭活疫苗在三个猪群中进行了评估（猪群A：无特定病原体猪群，猪群B：健康状况良好且无呼吸道感染临床症状的猪群，猪群C：健康状况较差且存在严重流行病学和经济问题的猪群）。来自这三个猪群的总共212头猪被分为两组。一组每隔4周注射两次疫苗，另一组为对照组。在任何一个猪群中，接种疫苗的猪在全身或局部均未出现不良反应。在猪群A中，第二次接种疫苗后4周内产生了抗体反应，且抗体反应持续超过12周。在猪群B和C中，与对照组相比，接种疫苗组的肺部病变猪数量、肺部病变平均百分比以及屠宰时从猪体内分离出的猪肺炎支原体数量均显著减少（P < 0.05）。此外，接种疫苗使猪群C的平均日增重（ADG）提高、饲料转化率（FCR）改善以及达到上市体重的天数减少，而猪群B的生长性能未显示出差异。结果表明，由猪肺炎支原体肉汤培养上清液制备的灭活疫苗在减轻临床症状和肺部病变方面是有效的。此外，在临床症状和经济损失显著的猪群中，接种疫苗可改善生长性能。
