Le Grand A, Kobisch M
Ecole nationale vétérinaire de Lyon, Marcy-l'Etoile, France.
Vet Res. 1996;27(3):241-53.
The purpose of this study was to compare the efficacy of Mycoplasma hyopneumoniae vaccination with pulse medication in a pig herd chronically infected with Mycoplasma hyopneumoniae. Control groups of pigs were compared to vaccinated or treated groups. Medication and vaccination induced a significant reduction of pneumonia score (46.37% and 29.8% respectively, compared to 53.85% for control groups, p < 0.05). The treatment did not induce a significant reduction of the mean range of lung lesions (3.75) compared to the control groups (4.25). The mean range of lung lesions was significantly reduced by vaccine (3.06, p < 0.005) but not by treatment. Neither the medication nor the vaccination were able to clear M hyopneumoniae or Pasteurella multocida from lung tissue. In this herd, the vaccination had a beneficial effect on daily weight gain of pigs (695.9 g/day compared to 683.1 g/day for the control groups). The improvement of the age at slaughtering was 1.3 days for treated groups and 2.4 days for vaccinated groups compared to control groups. The vaccination induced a significant improvement in muscle rate (57.05%) compared to control groups (56.41%, p < 0.05) and to treated groups (56.21%, p < 0.001). In this herd infected with M hyopneumoniae, after allowing for treatment cost, manpower excepted, the increase in value was from -3 FF to -11 FF for the antibiotic treatment and +10.4 FF for the vaccination. From economical and medical points of view, the vaccination was preferable to the treatment under the conditions described in this study.
本研究的目的是比较猪肺炎支原体疫苗接种与脉冲投药法对长期感染猪肺炎支原体猪群的疗效。将对照组猪与接种疫苗组或治疗组猪进行比较。药物治疗和疫苗接种均使肺炎评分显著降低(分别为46.37%和29.8%,对照组为53.85%,p<0.05)。与对照组(4.25)相比,治疗并未使肺部病变的平均范围显著降低(3.75)。疫苗使肺部病变的平均范围显著降低(3.06,p<0.005),但治疗未使其降低。药物治疗和疫苗接种均未能清除肺组织中的猪肺炎支原体或多杀性巴氏杆菌。在该猪群中,疫苗接种对猪的日增重有有益影响(695.9克/天,对照组为683.1克/天)。与对照组相比,治疗组的屠宰年龄改善了1.3天,疫苗接种组改善了2.4天。与对照组(56.41%,p<0.05)和治疗组(56.21%,p<0.001)相比,疫苗接种使肌肉率显著提高(57.05%)。在这个感染猪肺炎支原体的猪群中,除人力外,考虑治疗成本后,抗生素治疗的价值增加从-3法郎降至-11法郎,疫苗接种的价值增加为+10.4法郎。从经济和医学角度来看,在本研究所述条件下,疫苗接种优于治疗。