Kristensen Charlotte S, Vinther Jens, Svensmark Birgitta, Bækbo Poul
Danish Agriculture and Food Council, Pig Research Centre, Vinkelvej 11, DK-8620 Kjellerup, Denmark.
Acta Vet Scand. 2014 Apr 16;56(1):24. doi: 10.1186/1751-0147-56-24.
A field trial was carried out with two Mycoplasma hyopneumoniae vaccines in order to investigate the benefit of vaccination under field conditions in modern Danish pig production facilities with pigs being positive for M. hyopneumoniae. The M. hyopneumoniae infection of the herd was confirmed through blood samples that were positive for antibodies against M. hyopneumoniae combined with gross lesions of the lungs related to M. hyopneumoniae at slaughter and detection of M. hyopneumoniae by polymerace chain reaction in these lesions.
A total of 2,256 pigs from two herds were randomly divided into three groups. Group 1 received 2 mL ThoroVAX®VET, Group 2 received 1 mL Ingelvac®MycoFLEX, and Group 3 was a non-vaccinated control group. The vaccination was performed by a person who was not involved in the rest of the trial and vaccination status thereby blinded to the evaluators.The prevalence of lung lesions related to M. hyopneumoniae were significantly lower for pigs vaccinated with ThoroVAX®VET but not for pigs vaccinated with Ingelvac®MycoFLEX®, when compared to non-vaccinated pigs. There was no significant effect of vaccination on growth rate, antibiotic consumption or mortality.
This trial demonstrated that vaccination with Thoro®VAX VET was effective in reducing the prevalence of lung lesion in pig units infected with M. hyopneumoniae.
进行了一项针对两种猪肺炎支原体疫苗的田间试验，以调查在现代丹麦养猪生产设施中，猪肺炎支原体呈阳性的情况下接种疫苗的益处。通过检测针对猪肺炎支原体抗体呈阳性的血样、结合屠宰时与猪肺炎支原体相关的肺部肉眼病变以及在这些病变中通过聚合酶链反应检测猪肺炎支原体，确认了猪群的猪肺炎支原体感染情况。
来自两个猪群的总共2256头猪被随机分为三组。第1组接种2毫升ThoroVAX®VET，第2组接种1毫升Ingelvac®MycoFLEX，第3组为未接种疫苗的对照组。疫苗接种由未参与试验其他部分的人员进行，因此评估人员对疫苗接种状态不知情。与未接种疫苗的猪相比，接种ThoroVAX®VET的猪中与猪肺炎支原体相关的肺部病变患病率显著降低，但接种Ingelvac®MycoFLEX的猪则没有。疫苗接种对生长速度、抗生素使用量或死亡率没有显著影响。
该试验表明，使用Thoro®VAX VET疫苗接种可有效降低感染猪肺炎支原体的猪群中肺部病变的患病率。
