Schachtele D F, Leung W L
J Dent Res. 1975 May-Jun;54(3):433-40. doi: 10.1177/00220345750540030301.
Studies on the effect of various structural analogues of glucose of phosphoenolpyruvate (PEP)-dependent sugar transport in Streptococcus mutans showed that sugars with alterations at carbon 2 were markedly inhibitory. Low concentrations of the nonfermentable analogue D-2-deoxyglucose (2-deoxyg) blocked the growth of S mutans in broth media containing various fermentable sugars. Acid production by S mutans from both exogenous glucose and intracellular storage polysaccharide was inhibited by 2-deoxyG. The analogue is bacteriostatic, and large quantities of intracellular 2-deoxyG-6-PO4 accumulate during exposure of S mutans to the sugar.
关于磷酸烯醇丙酮酸（PEP）依赖性糖转运在变形链球菌中各种葡萄糖结构类似物作用的研究表明，在碳2处有改变的糖具有显著抑制作用。低浓度的非发酵类似物D - 2 - 脱氧葡萄糖（2 - deoxyg）可阻断变形链球菌在含有各种可发酵糖的肉汤培养基中的生长。2 - 脱氧葡萄糖抑制了变形链球菌从外源葡萄糖和细胞内储存多糖产生酸的过程。该类似物具有抑菌作用，在变形链球菌接触该糖的过程中，大量细胞内的2 - 脱氧葡萄糖 - 6 - 磷酸会积累。
