变形链球菌中己糖醇分解代谢的调控
Regulation of hexitol catabolism in Streptococcus mutans.
作者信息
Dills S S, Seno S
出版信息
J Bacteriol. 1983 Feb;153(2):861-6. doi: 10.1128/jb.153.2.861-866.1983.
Abstract
Regulation of hexitol catabolism was investigated in Streptococcus mutans, a cariogenic human dental plaque bacterium. Induction of hexitol catabolic enzymes and phosphoenolpyruvate:hexitol phosphotransferase and hexitol phosphate dehydrogenase activities was regulated by an inducer exclusion mechanism initiated by D-glucose and 2-deoxy-D-glucose. Kinetic analysis of the inhibitory effect of 2-deoxy-D-glucose on initial hexitol uptake illustrated that this was a noncompetitive type of inhibition. In mutant strains of S. mutans lacking phosphoenolpyruvate:glucose phosphotransferase activity, 2-deoxy-D-glucose was unable to inhibit hexitol uptake. These observations provide evidence for possible molecular mechanisms for the exclusion process.
摘要
在变形链球菌（一种致龋的人类牙菌斑细菌）中研究了己糖醇分解代谢的调控。己糖醇分解代谢酶以及磷酸烯醇丙酮酸：己糖醇磷酸转移酶和己糖醇磷酸脱氢酶活性的诱导受由D-葡萄糖和2-脱氧-D-葡萄糖引发的诱导物排除机制调控。对2-脱氧-D-葡萄糖对己糖醇初始摄取的抑制作用的动力学分析表明这是一种非竞争性抑制类型。在缺乏磷酸烯醇丙酮酸：葡萄糖磷酸转移酶活性的变形链球菌突变株中，2-脱氧-D-葡萄糖无法抑制己糖醇摄取。这些观察结果为排除过程的可能分子机制提供了证据。
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