Sacks H S, Shahshahani M, Kitabchi A E, Fisher J N, Young R T
Ann Intern Med. 1979 Jan;90(1):36-42. doi: 10.7326/0003-4819-90-1-36.
We compared low-dose insulin regimens in a prospective randomized trial in 30 patients with diabetic ketoacidosis. One group received a loading dose of 0.44 U/kg body weight of regular insulin half intramuscularly and half intravenously followed by 7 U/h intramuscularly, whereas the other group received a loading dose of 0.44 U/kg intravenously followed immediately by a constant infusion of 7 U/h in albumin-free saline. The time for metabolic control of the ketoacidosis was not significantly different in the two groups. Five patients in each group developed mild hypokalemia (serum potassium, 3.0 to 3.4 meq/litre). No patient became hypoglycemic, and there were no deaths within the follow-up period (24 h). In the treatment of diabetic ketoacidosis, low doses of insulin administered by the priming dose-intermittent intramuscular route are as effective as the constant infusion method.
我们在一项针对30例糖尿病酮症酸中毒患者的前瞻性随机试验中比较了低剂量胰岛素治疗方案。一组接受0.44 U/kg体重的正规胰岛素负荷剂量，一半肌肉注射，一半静脉注射，随后7 U/h肌肉注射；而另一组接受0.44 U/kg静脉负荷剂量，随后立即在无白蛋白盐水中以7 U/h持续输注。两组酮症酸中毒代谢控制的时间无显著差异。每组有5例患者出现轻度低钾血症（血清钾，3.0至3.4 meq/升）。无患者发生低血糖，随访期（24小时）内无死亡病例。在糖尿病酮症酸中毒的治疗中，通过首剂间歇肌肉注射途径给予低剂量胰岛素与持续输注方法同样有效。
