Smrcková I, Charvát J, Malá D, Lácha J
Pracovistĕ specializovaných laboratorí, Klinika nefrologie IKEM, Praha.
Cas Lek Cesk. 1999 Jun 28;138(13):406-8.
Negative interference of bilirubin with assessment of creatinine concentration is generally known from the biochemical aspect. The objective of the presented work was to find the bilirubin level and creatinine concentration where this phenomenon has actually a clinical impact.
In 200 samples selected at random the bilirubin and creatinine levels were examined by the classical Jaffé method and a method where the effect of bilirubin is suppressed. After dividing the group into 8 sub-groups by bilirubin and creatinine concentrations it was revealed that the interference plays a statistically significant role (p < 0.01) already at total bilirubin concentrations above 70 mumol.l-1. In abnormal creatinine levels the interference is manifested only at bilirubin concentrations above 150 mumol.l-1 (p < 0.001). The degree of interference in the whole group is directly proportional to the bilirubin level (r = 0.5497, p < 0.001).
At bilirubin levels above 70 to 150 mumol.l-1 its interference with assessment of the creatinine concentration can be so significant that it must be taken into account when evaluating the patient's renal function.
从生化角度来看，胆红素对肌酐浓度评估的负干扰是众所周知的。本研究的目的是找出这种现象在临床上产生实际影响时的胆红素水平和肌酐浓度。
随机选取200份样本，采用经典的Jaffe法和一种抑制胆红素影响的方法检测胆红素和肌酐水平。按胆红素和肌酐浓度将该组分为8个亚组后发现，当总胆红素浓度高于70μmol·l⁻¹时，这种干扰就已具有统计学意义（p < 0.01）。在肌酐水平异常时，干扰仅在胆红素浓度高于150μmol·l⁻¹时才表现出来（p < 0.001）。整个组中干扰程度与胆红素水平成正比（r = 0.5497，p < 0.001）。
当胆红素水平高于70至150μmol·l⁻¹时，其对肌酐浓度评估的干扰可能非常显著，在评估患者肾功能时必须予以考虑。
