• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

β-淀粉样蛋白与过氧化氢酶高亲和力结合并抑制过氧化氢分解。

Amyloid-beta binds catalase with high affinity and inhibits hydrogen peroxide breakdown.

作者信息

Milton N G

机构信息

Department of Molecular Pathology, Royal Free and University College Medical School, University College London, Royal Free Campus, Rowland Hill Street, London NW3 2PF, U.K.

出版信息

Biochem J. 1999 Dec 1;344 Pt 2(Pt 2):293-6.

PMID:10567208
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1220643/
Abstract

Amyloid-beta (Abeta) specifically bound purified catalase with high affinity and inhibited catalase breakdown of H(2)O(2). The Abeta-induced catalase inhibition involved formation of the inactive catalase Compound II and was reversible. Catalase<-->Abeta interactions provide rapid functional assays for the cytotoxic domain of Abeta and suggest a mechanism for some of the observed actions of Abeta plus catalase in vitro.

摘要

β淀粉样蛋白（Aβ）以高亲和力特异性结合纯化的过氧化氢酶，并抑制过氧化氢酶对H₂O₂的分解。Aβ诱导的过氧化氢酶抑制作用涉及无活性的过氧化氢酶化合物II的形成，且是可逆的。过氧化氢酶与Aβ的相互作用为Aβ的细胞毒性结构域提供了快速功能测定方法，并提示了体外观察到的Aβ加过氧化氢酶某些作用的机制。

相似文献

1
Amyloid-beta binds catalase with high affinity and inhibits hydrogen peroxide breakdown.β-淀粉样蛋白与过氧化氢酶高亲和力结合并抑制过氧化氢分解。
Biochem J. 1999 Dec 1;344 Pt 2(Pt 2):293-6.
2
Methionine 35 oxidation reduces toxic effects of the amyloid beta-protein fragment (31-35) on human red blood cell.甲硫氨酸35氧化可降低淀粉样β蛋白片段（31 - 35）对人红细胞的毒性作用。
Int J Biochem Cell Biol. 2004 Oct;36(10):2066-76. doi: 10.1016/j.biocel.2004.03.006.
3
Mechanism of hydrogen peroxide production by copper-bound amyloid beta peptide: a theoretical study.铜结合淀粉样β肽产生过氧化氢的机制：一项理论研究。
J Phys Chem B. 2009 Jan 29;113(4):1202-9. doi: 10.1021/jp807327a.
4
Human apolipoprotein A-I binds amyloid-beta and prevents Abeta-induced neurotoxicity.人类载脂蛋白A-I与β淀粉样蛋白结合并预防β淀粉样蛋白诱导的神经毒性。
Int J Biochem Cell Biol. 2009 Jun;41(6):1361-70. doi: 10.1016/j.biocel.2008.12.003. Epub 2008 Dec 14.
5
Amyloid beta-peptide(1-42) and hydrogen peroxide-induced toxicity are mediated by TRPM2 in rat primary striatal cultures.在大鼠原代纹状体培养物中，β-淀粉样蛋白（1-42）和过氧化氢诱导的毒性由瞬时受体电位阳离子通道亚家族M成员2（TRPM2）介导。
J Neurochem. 2005 Nov;95(3):715-23. doi: 10.1111/j.1471-4159.2005.03396.x. Epub 2005 Aug 16.
6
Beta-amyloid-derived pentapeptide RIIGLa inhibits Abeta(1-42) aggregation and toxicity.β-淀粉样蛋白衍生的五肽RIIGLa抑制β-淀粉样蛋白（1-42）的聚集和毒性。
Biochem Biophys Res Commun. 2004 Nov 5;324(1):64-9. doi: 10.1016/j.bbrc.2004.09.024.
7
Humoral immune response to fibrillar beta-amyloid peptide.对纤维状β-淀粉样肽的体液免疫反应。
Biochemistry. 2003 Oct 14;42(40):11682-92. doi: 10.1021/bi030100s.
8
Binding of cystatin C to Alzheimer's amyloid beta inhibits in vitro amyloid fibril formation.胱抑素C与阿尔茨海默病β淀粉样蛋白的结合可抑制体外淀粉样纤维的形成。
Neurobiol Aging. 2004 Sep;25(8):1033-43. doi: 10.1016/j.neurobiolaging.2003.11.006.
9
CLAC binds to aggregated Abeta and Abeta fragments, and attenuates fibril elongation.CLAC与聚集的β-淀粉样蛋白（Aβ）及其片段结合，并减弱纤维伸长。
Biochemistry. 2005 Nov 29;44(47):15602-9. doi: 10.1021/bi051263e.
10
Specific binding of amyloid-beta-protein to IMR-32 neuroblastoma cell membrane.β-淀粉样蛋白与IMR-32神经母细胞瘤细胞膜的特异性结合。
J Pept Res. 2005 May;65(5):485-90. doi: 10.1111/j.1399-3011.2005.00250.x.

引用本文的文献

1
Several lines of antioxidant defense against oxidative stress: antioxidant enzymes, nanomaterials with multiple enzyme-mimicking activities, and low-molecular-weight antioxidants.抗氧化防御系统应对氧化应激的几种途径：抗氧化酶、具有多种酶模拟活性的纳米材料和低分子量抗氧化剂。
Arch Toxicol. 2024 May;98(5):1323-1367. doi: 10.1007/s00204-024-03696-4. Epub 2024 Mar 14.
2
Betaine attenuates oxidative stress and cognitive dysfunction in an amyloid β-induced rat model of Alzheimer's disease.甜菜碱可减轻淀粉样蛋白β诱导的阿尔茨海默病大鼠模型中的氧化应激和认知功能障碍。
Res Pharm Sci. 2023 Mar 10;18(3):270-278. doi: 10.4103/1735-5362.371583. eCollection 2023 May-Jun.
3
The Effect of the Sodium-Glucose Cotransporter Inhibitor on Cognition and Metabolic Parameters in a Rat Model of Sporadic Alzheimer's Disease.钠-葡萄糖协同转运蛋白抑制剂对散发性阿尔茨海默病大鼠模型认知及代谢参数的影响
Biomedicines. 2023 Mar 27;11(4):1025. doi: 10.3390/biomedicines11041025.
4
An Interactive Review on the Role of Tocotrienols in the Neurodegenerative Disorders.生育三烯酚在神经退行性疾病中的作用的交互式综述
Front Nutr. 2021 Oct 26;8:754086. doi: 10.3389/fnut.2021.754086. eCollection 2021.
5
Single Point Mutation from E22-to-K in A Initiates Early-Onset Alzheimer's Disease by Binding with Catalase.E22 到 K 的单点突变通过与过氧化氢酶结合引发早发性阿尔茨海默病。
Oxid Med Cell Longev. 2020 Dec 24;2020:4981204. doi: 10.1155/2020/4981204. eCollection 2020.
6
Analysis of brain region-specific co-expression networks reveals clustering of established and novel genes associated with Alzheimer disease.分析大脑区域特异性共表达网络揭示了与阿尔茨海默病相关的已建立和新基因的聚类。
Alzheimers Res Ther. 2020 Sep 2;12(1):103. doi: 10.1186/s13195-020-00674-7.
7
Therapeutic Potential of Vitamin D and Curcumin in an Model of Alzheimer Disease.维生素D与姜黄素在阿尔茨海默病模型中的治疗潜力
J Cent Nerv Syst Dis. 2020 May 27;12:1179573520924311. doi: 10.1177/1179573520924311. eCollection 2020.
8
The human brainome: network analysis identifies HSPA2 as a novel Alzheimer&rsquo;s disease target.人类脑图谱：网络分析确定 HSPA2 为阿尔茨海默病的新靶点。
Brain. 2018 Sep 1;141(9):2721-2739. doi: 10.1093/brain/awy215.
9
Autophagy Activation Alleviates Amyloid-β-Induced Oxidative Stress, Apoptosis and Neurotoxicity in Human Neuroblastoma SH-SY5Y Cells.自噬激活减轻人神经母细胞瘤 SH-SY5Y 细胞中淀粉样β诱导的氧化应激、细胞凋亡和神经毒性。
Neurotox Res. 2017 Oct;32(3):351-361. doi: 10.1007/s12640-017-9746-5. Epub 2017 May 8.
10
Targeted Antioxidant, Catalase-SKL, Reduces Beta-Amyloid Toxicity in the Rat Brain.靶向抗氧化剂过氧化氢酶-SKL可降低大鼠脑中β-淀粉样蛋白的毒性。
Brain Pathol. 2017 Jan;27(1):86-94. doi: 10.1111/bpa.12368. Epub 2016 Jun 13.

本文引用的文献

1
The A beta peptide of Alzheimer's disease directly produces hydrogen peroxide through metal ion reduction.阿尔茨海默病的Aβ肽通过金属离子还原直接产生过氧化氢。
Biochemistry. 1999 Jun 15;38(24):7609-16. doi: 10.1021/bi990438f.
2
Beta-sheet breaker peptides inhibit fibrillogenesis in a rat brain model of amyloidosis: implications for Alzheimer's therapy.β-折叠破坏肽在淀粉样变性大鼠脑模型中抑制纤维形成：对阿尔茨海默病治疗的意义。
Nat Med. 1998 Jul;4(7):822-6. doi: 10.1038/nm0798-822.
3
Resistance to the apoptotic effect of aggregated amyloid-beta peptide in several different cell types including neuronal- and hepatoma-derived cell lines.包括神经元和肝癌衍生细胞系在内的几种不同细胞类型对聚集的淀粉样β肽的凋亡作用具有抗性。
Biochem J. 1998 Jun 1;332 ( Pt 2)(Pt 2):517-24. doi: 10.1042/bj3320517.
4
Binding of beta-amyloid to the p75 neurotrophin receptor induces apoptosis. A possible mechanism for Alzheimer's disease.β-淀粉样蛋白与p75神经营养因子受体的结合会诱导细胞凋亡。这是阿尔茨海默病的一种可能机制。
J Clin Invest. 1997 Nov 1;100(9):2333-40. doi: 10.1172/JCI119772.
5
An intracellular protein that binds amyloid-beta peptide and mediates neurotoxicity in Alzheimer's disease.一种与β淀粉样肽结合并在阿尔茨海默病中介导神经毒性的细胞内蛋白质。
Nature. 1997 Oct 16;389(6652):689-95. doi: 10.1038/39522.
6
A putative tetrapeptide antagonist prevents beta-amyloid-induced long-term elevation of [Ca2+]i in rat astrocytes.一种假定的四肽拮抗剂可阻止β-淀粉样蛋白诱导的大鼠星形胶质细胞内[Ca2+]i长期升高。
Biochem Biophys Res Commun. 1997 Jun 27;235(3):479-81. doi: 10.1006/bbrc.1997.6806.
7
Amyloid beta-mediated oxidative and metabolic stress in rat cortical neurons: no direct evidence for a role for H2O2 generation.β-淀粉样蛋白介导的大鼠皮质神经元氧化和代谢应激：没有关于过氧化氢生成作用的直接证据。
J Neurochem. 1996 Oct;67(4):1595-606. doi: 10.1046/j.1471-4159.1996.67041595.x.
8
Rapid cellular uptake of Alzheimer amyloid betaA4 peptide by cultured human neuroblastoma cells.培养的人神经母细胞瘤细胞对阿尔茨海默病β淀粉样蛋白A4肽的快速细胞摄取。
FEBS Lett. 1996 Sep 30;394(2):174-8. doi: 10.1016/0014-5793(96)00948-9.
9
Analysis of heterogeneous A4 peptides in human cerebrospinal fluid and blood by a newly developed sensitive Western blot assay.通过新开发的灵敏蛋白质印迹分析法分析人脑脊液和血液中的异质A4肽。
J Biol Chem. 1996 Sep 13;271(37):22908-14. doi: 10.1074/jbc.271.37.22908.
10
Amyloid beta-protein reduces acetylcholine synthesis in a cell line derived from cholinergic neurons of the basal forebrain.β-淀粉样蛋白可降低源自基底前脑胆碱能神经元的细胞系中的乙酰胆碱合成。
Proc Natl Acad Sci U S A. 1996 Jul 23;93(15):8068-71. doi: 10.1073/pnas.93.15.8068.