Ernst R K, Yi E C, Guo L, Lim K B, Burns J L, Hackett M, Miller S I
Department of Medicine, University of Washington, Seattle, WA 98195, USA.
Science. 1999 Nov 19;286(5444):1561-5. doi: 10.1126/science.286.5444.1561.
Cystic fibrosis (CF) patients develop chronic airway infections with Pseudomonas aeruginosa (PA). Pseudomonas aeruginosa synthesized lipopolysaccharide (LPS) with a variety of penta- and hexa-acylated lipid A structures under different environmental conditions. CF patient PA synthesized LPS with specific lipid A structures indicating unique recognition of the CF airway environment. CF-specific lipid A forms containing palmitate and aminoarabinose were associated with resistance to cationic antimicrobial peptides and increased inflammatory responses, indicating that they are likely to be involved in airway disease.
囊性纤维化（CF）患者会发生铜绿假单胞菌（PA）引起的慢性气道感染。铜绿假单胞菌在不同环境条件下合成具有多种五酰化和六酰化脂质A结构的脂多糖（LPS）。CF患者的PA合成具有特定脂质A结构的LPS，这表明其对CF气道环境有独特的识别。含有棕榈酸酯和氨基阿拉伯糖的CF特异性脂质A形式与对阳离子抗菌肽的抗性和炎症反应增加有关，表明它们可能参与气道疾病。
