Ernst Robert K, Moskowitz Samuel M, Emerson Julia C, Kraig Gretchen M, Adams Kristin N, Harvey Megan D, Ramsey Bonnie, Speert David P, Burns Jane L, Miller Samuel I
Department of Medicine, University of Washington, Seattle, WA 98195, USA.
J Infect Dis. 2007 Oct 1;196(7):1088-92. doi: 10.1086/521367. Epub 2007 Aug 22.
Three structural features of lipid A (addition of palmitate [C16 fatty acid], addition of aminoarabinose [positively charged amino sugar residue], and retention of 3-hydroxydecanoate [3-OH C10 fatty acid]) were determined for Pseudomonas aeruginosa isolates from patients with cystic fibrosis (CF; n=86), from the environment (n=13), and from patients with other conditions (n=14). Among P. aeruginosa CF isolates, 100% had lipid A with palmitate, 24.6% with aminoarabinose, and 33.3% retained 3-hydroxydecanoate. None of the isolates from the environment or from patients with other conditions displayed these modifications. These results indicate that unique lipid A modifications occur in clinical P. aeruginosa CF isolates.
对来自囊性纤维化（CF）患者（n = 86）、环境（n = 13）和其他病症患者（n = 14）的铜绿假单胞菌分离株，确定了脂多糖A的三个结构特征（添加棕榈酸酯[C16脂肪酸]、添加氨基阿拉伯糖[带正电荷的氨基糖残基]和保留3-羟基癸酸[3-OH C10脂肪酸]）。在铜绿假单胞菌CF分离株中，100%的脂多糖A含有棕榈酸酯，24.6%含有氨基阿拉伯糖，33.3%保留3-羟基癸酸。来自环境或其他病症患者的分离株均未表现出这些修饰。这些结果表明，临床铜绿假单胞菌CF分离株中出现了独特的脂多糖A修饰。
