从囊性纤维化患者气道分离出的铜绿假单胞菌中独特的脂多糖A修饰。
Unique lipid a modifications in Pseudomonas aeruginosa isolated from the airways of patients with cystic fibrosis.
作者信息
Ernst Robert K, Moskowitz Samuel M, Emerson Julia C, Kraig Gretchen M, Adams Kristin N, Harvey Megan D, Ramsey Bonnie, Speert David P, Burns Jane L, Miller Samuel I
机构信息
Department of Medicine, University of Washington, Seattle, WA 98195, USA.
出版信息
J Infect Dis. 2007 Oct 1;196(7):1088-92. doi: 10.1086/521367. Epub 2007 Aug 22.
Abstract
Three structural features of lipid A (addition of palmitate [C16 fatty acid], addition of aminoarabinose [positively charged amino sugar residue], and retention of 3-hydroxydecanoate [3-OH C10 fatty acid]) were determined for Pseudomonas aeruginosa isolates from patients with cystic fibrosis (CF; n=86), from the environment (n=13), and from patients with other conditions (n=14). Among P. aeruginosa CF isolates, 100% had lipid A with palmitate, 24.6% with aminoarabinose, and 33.3% retained 3-hydroxydecanoate. None of the isolates from the environment or from patients with other conditions displayed these modifications. These results indicate that unique lipid A modifications occur in clinical P. aeruginosa CF isolates.
摘要
对来自囊性纤维化（CF）患者（n = 86）、环境（n = 13）和其他病症患者（n = 14）的铜绿假单胞菌分离株，确定了脂多糖A的三个结构特征（添加棕榈酸酯[C16脂肪酸]、添加氨基阿拉伯糖[带正电荷的氨基糖残基]和保留3-羟基癸酸[3-OH C10脂肪酸]）。在铜绿假单胞菌CF分离株中，100%的脂多糖A含有棕榈酸酯，24.6%含有氨基阿拉伯糖，33.3%保留3-羟基癸酸。来自环境或其他病症患者的分离株均未表现出这些修饰。这些结果表明，临床铜绿假单胞菌CF分离株中出现了独特的脂多糖A修饰。
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