帕金森病：一种用于确定黑质结构变化的新型磁共振成像方法。
Parkinson's disease: a novel MRI method for determining structural changes in the substantia nigra.
作者信息
Hutchinson M, Raff U
机构信息
Department of Neurology, NYU School of Medicine, 550 First Avenue, New York, NY 10016, USA.
出版信息
J Neurol Neurosurg Psychiatry. 1999 Dec;67(6):815-8. doi: 10.1136/jnnp.67.6.815.
OBJECTIVES
To use MRI in a novel way to image and quantify the changes occurring in the substantia nigra in Parkinson's disease.
METHODS
Six patients with idiopathic Parkinson's disease were compared with six age matched control subjects. The subjects were imaged using a combination of pulse sequences hypothesised to be sensitive to cell loss.
RESULTS
The images showed patterns of change in patients with Parkinson's disease. Highly significant differences between the patients and control population were found (p<0.001).
CONCLUSIONS
This methodology suggests the possibility of detecting presymptomatic disease in those judged to be at risk, and also in confirming the diagnosis in patients with early disease. Furthermore, the technique seems to hold promise as a means for staging the disease, and possibly differentiating other forms of parkinsonism.
目的
以一种全新的方式利用磁共振成像（MRI）对帕金森病黑质中发生的变化进行成像和量化。
方法
将6例特发性帕金森病患者与6例年龄匹配的对照受试者进行比较。使用一组假定对细胞丢失敏感的脉冲序列组合对受试者进行成像。
结果
图像显示了帕金森病患者的变化模式。患者与对照人群之间存在高度显著差异（p<0.001）。
结论
该方法表明有可能在被判定有风险的人群中检测出症状前疾病，也能在早期疾病患者中确诊。此外，该技术似乎有望作为一种对疾病进行分期的手段，并且有可能区分其他形式的帕金森综合征。
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