泛素介导的蛋白质降解的调控模式。
Modes of regulation of ubiquitin-mediated protein degradation.
作者信息
Kornitzer D, Ciechanover A
机构信息
Department of Molecular Microbiology, The Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.
出版信息
J Cell Physiol. 2000 Jan;182(1):1-11. doi: 10.1002/(SICI)1097-4652(200001)182:1<1::AID-JCP1>3.0.CO;2-V.
The ubiquitin-proteasome pathway is responsible for the major portion of specific cellular protein degradation. Ubiquitin-mediated degradation is involved in physiological regulation of many cellular processes, including cell cycle progression, differentiation, and signal transduction. Here, we review the basic mechanisms of the ubiquitin system and the various ways in which ubiquitin-mediated degradation can be modulated by physiological signals.
泛素-蛋白酶体途径负责特定细胞蛋白质降解的主要部分。泛素介导的降解参与许多细胞过程的生理调节，包括细胞周期进程、分化和信号转导。在此，我们综述泛素系统的基本机制以及泛素介导的降解可被生理信号调节的各种方式。
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