The ubiquitin-proteasome pathway: on protein death and cell life.
作者信息
Ciechanover A
机构信息
Department of Biochemistry, The Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, P.O.Box 9649, Efron Street, Bat Galim, Haifa 31096,
出版信息
EMBO J. 1998 Dec 15;17(24):7151-60. doi: 10.1093/emboj/17.24.7151.
Abstract
摘要
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本文引用的文献
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A novel site for ubiquitination: the N-terminal residue, and not internal lysines of MyoD, is essential for conjugation and degradation of the protein.一种新型泛素化位点：MyoD的N端残基而非内部赖氨酸对于该蛋白的缀合和降解至关重要。
EMBO J. 1998 Oct 15;17(20):5964-73. doi: 10.1093/emboj/17.20.5964.
2
A protein conjugation system essential for autophagy.一种自噬所必需的蛋白质偶联系统。
Nature. 1998 Sep 24;395(6700):395-8. doi: 10.1038/26506.
3
The ubiquitin system.泛素系统。
Annu Rev Biochem. 1998;67:425-79. doi: 10.1146/annurev.biochem.67.1.425.
4
Degradation of myogenic transcription factor MyoD by the ubiquitin pathway in vivo and in vitro: regulation by specific DNA binding.体内外泛素途径介导的生肌转录因子MyoD降解：特异性DNA结合的调控作用
Mol Cell Biol. 1998 Oct;18(10):5670-7. doi: 10.1128/MCB.18.10.5670.
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SUMO-1 modification of IkappaBalpha inhibits NF-kappaB activation.IkappaBalpha的SUMO-1修饰抑制核因子-κB激活。
Mol Cell. 1998 Aug;2(2):233-9. doi: 10.1016/s1097-2765(00)80133-1.
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Degradation signal masking by heterodimerization of MATalpha2 and MATa1 blocks their mutual destruction by the ubiquitin-proteasome pathway.MATalpha2和MATa1通过异源二聚化进行降解信号屏蔽，从而阻止它们被泛素-蛋白酶体途径相互破坏。
Cell. 1998 Jul 24;94(2):217-27. doi: 10.1016/s0092-8674(00)81421-x.
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A function for monoubiquitination in the internalization of a G protein-coupled receptor.单泛素化在G蛋白偶联受体内化过程中的作用。
Mol Cell. 1998 Jan;1(2):193-202. doi: 10.1016/s1097-2765(00)80020-9.
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A giant ubiquitin-conjugating enzyme related to IAP apoptosis inhibitors.一种与IAP凋亡抑制因子相关的巨大泛素结合酶。
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Biochem J. 1998 Jun 15;332 ( Pt 3)(Pt 3):749-54. doi: 10.1042/bj3320749.
10
Chaperone suppression of aggregation and altered subcellular proteasome localization imply protein misfolding in SCA1.伴侣蛋白对聚集的抑制作用以及亚细胞蛋白酶体定位的改变表明脊髓小脑共济失调1型中存在蛋白质错误折叠。
Nat Genet. 1998 Jun;19(2):148-54. doi: 10.1038/502.
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