Leder A, Leder P
Cell. 1975 Jul;5(3):319-22. doi: 10.1016/0092-8674(75)90107-5.
Butyric acid is an unusually potent inducer of erythroid differentiation in cultured erythroleukemic cells. It is effective at one hundredth the concentration required of dimethylsulfoxide, a most effective inducing agent. Studies using a variety of analogues and metabolites suggest that the structural features of butyric acid are rather stringently required for induction. This effect is considered in view of the fact that butyric acid is a naturally occurring fatty acid, is effective in relatively low concentrations, and is widely used to form derivatives of cAMP.
丁酸是培养的红白血病细胞中一种异常有效的红细胞分化诱导剂。它的有效浓度是最有效的诱导剂二甲基亚砜所需浓度的百分之一。使用各种类似物和代谢物进行的研究表明，丁酸的结构特征对于诱导作用相当严格。鉴于丁酸是一种天然存在的脂肪酸，在相对较低的浓度下有效，并且被广泛用于形成环磷酸腺苷的衍生物，所以对这种效应进行了研究。
