Torén K, Järvholm B, Brisman J, Hagberg S, Hermansson B A, Lillienberg L
Department of Occupational and Environmental Medicine, Sahlgrenska University Hospital, Göteborg, Sweden.
Scand J Work Environ Health. 1999 Oct;25(5):430-5. doi: 10.5271/sjweh.456.
This study examined certain occupational exposures and the risk for adult-onset asthma.
A nested case-referent study of adult-onset asthma was performed on a random population sample (N=15813), aged 21 to 51 years. Cases for the study included 2 groups: subjects reporting "physician-diagnosed" asthma (N=251) and a broader "asthma" group (N=362). The "asthma" group consisted of subjects with "physician-diagnosed" asthma (N=251) and subjects reporting asthma-like symptoms without having "physician-diagnosed" asthma (N=111). The referents (N=2044) were randomly selected from the whole population sample. The case-referent sample was investigated with a comprehensive questionnaire about occupational exposures, asthma, respiratory symptoms, smoking, and atopy. Odds ratios were calculated with stratification for gender, year of diagnosis, and birth year.
The highest odds ratio for "physician-diagnosed" asthma was associated with exposure to flour dust [odds ratio (OR) 2.8, 95% confidence interval (95% CI) 1.5-5.2] and the occupational handling of resin-based paints (isocyanates) (OR 3.0, 95% CI 1.6-5.9). Exposure to welding fumes, textile dust, and work with glues containing acrylates was also associated with an increased odds ratio for "physician-diagnosed" asthma. Including persons with asthma-like symptoms (ie, the asthma group) showed similar results.
This population-based case-referent study from Sweden indicates that occupational exposure to acrylate-based compounds and welding fumes is associated with increased risk for adult-onset asthma.
本研究调查了某些职业暴露与成人期哮喘风险之间的关系。
对年龄在21至51岁之间的随机人群样本（N = 15813）进行了一项成人期哮喘的巢式病例对照研究。该研究的病例包括两组：报告“医生诊断的”哮喘的受试者（N = 251）和范围更广的“哮喘”组（N = 362）。“哮喘”组由患有“医生诊断的”哮喘的受试者（N = 251）和报告有哮喘样症状但未患有“医生诊断的”哮喘的受试者（N = 111）组成。对照（N = 2044）是从整个人群样本中随机选取的。通过一份关于职业暴露、哮喘、呼吸道症状、吸烟和特应性的综合问卷对病例对照样本进行了调查。计算了按性别、诊断年份和出生年份分层的比值比。
“医生诊断的”哮喘的最高比值比与接触面粉粉尘[比值比（OR）2.8，95%置信区间（95%CI）1.5 - 5.2]以及职业性接触树脂基涂料（异氰酸酯）（OR 3.0，95%CI 1.6 - 5.9）有关。接触焊接烟尘、纺织粉尘以及使用含丙烯酸酯的胶水工作也与“医生诊断的”哮喘的比值比升高有关。纳入有哮喘样症状的人（即哮喘组）显示出类似的结果。
这项来自瑞典的基于人群的病例对照研究表明，职业性接触丙烯酸酯类化合物和焊接烟尘与成人期哮喘风险增加有关。
