局部麻醉药作用的多因素分析
Multiple factor analysis of the action of local anesthetics.
作者信息
Lin H C, Ueda I, Eyring H
出版信息
Proc Natl Acad Sci U S A. 1976 Oct;73(10):3726-8. doi: 10.1073/pnas.73.10.3726.
Abstract
The pH jump data of Bianchi and Strobel [(1968) Trans. N.Y. Acad. Sci. Ser. II, 30, 1082-1092] on desheathed frog sciatic nerve are fitted to rate equations. A general quantitation of synergism, summation, and antagonism of anesthetics and of excitation is given.
摘要
比安基和斯特罗贝尔[(1968年)《纽约科学院学报》第二辑，30卷，1082 - 1092页]关于去鞘青蛙坐骨神经的pH跃变数据被拟合到速率方程中。给出了麻醉剂和兴奋的协同、总和及拮抗作用的一般定量分析。
相似文献
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Multiple factor analysis of the action of local anesthetics.局部麻醉药作用的多因素分析
Proc Natl Acad Sci U S A. 1976 Oct;73(10):3726-8. doi: 10.1073/pnas.73.10.3726.
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The action of local anaesthetics on the compound action potential is altered by the nature of the permeant ion in frog nerve.局部麻醉药对复合动作电位的作用会因蛙神经中通透离子的性质而改变。
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本文引用的文献
1
Local anesthetics. I. The blocking potencies of some local anesthetics and of butyl alcohol determined on peripheral nerves.局部麻醉药。一、某些局部麻醉药和丁醇对周围神经的阻滞效能
Acta Pharmacol Toxicol (Copenh). 1954;10(3):281-91. doi: 10.1111/j.1600-0773.1954.tb01344.x.
2
On the active structure of local anesthetics.论局部麻醉药的活性结构。
J Pharmacol Exp Ther. 1961 Aug;133:241-5.
3
The site of action and active form of local anesthetics. I. Theory and pH experiments with tertiary compounds.局部麻醉药的作用部位及活性形式。I. 叔胺化合物的理论与pH实验
J Pharmacol Exp Ther. 1970 Jan;171(1):32-44.
4
Modes of action of local anesthetics in nerve and muscle in relation to their uptake and distribution.局部麻醉药在神经和肌肉中的作用方式与其摄取和分布的关系。
Trans N Y Acad Sci. 1968 Jun;30(8):1082-92. doi: 10.1111/j.2164-0947.1968.tb02557.x.
5
[Protein binding of local anesthetics].[局部麻醉药的蛋白结合]
Masui. 1975 Mar;24(3):245-52.
6
Molecular mechanism of inhibition of firefly luminescence by local anesthetics.局部麻醉药抑制萤火虫发光的分子机制。
Proc Natl Acad Sci U S A. 1976 Feb;73(2):481-5. doi: 10.1073/pnas.73.2.481.
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