肾细胞癌：存在转移性疾病时是否应行根治性肾切除术？

Renal cell carcinoma: should radical nephrectomy be performed in the presence of metastatic disease?

作者信息

Sawczuk I S, Pollard J C

机构信息

Department of Urology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.

出版信息

Curr Opin Urol. 1999 Sep;9(5):377-81. doi: 10.1097/00042307-199909000-00002.

DOI:10.1097/00042307-199909000-00002

PMID:10579074

Abstract

Metastatic renal cell carcinoma is associated with an unfavorable prognosis and the treatment options are limited. Adjunctive radical nephrectomy, performed either before or after the administration of systemic immunotherapy, has been proposed as a means of improving outcome. The role of nephrectomy for patients with metastatic disease remains controversial. This article reviews the role of nephrectomy in metastatic renal cell carcinoma and the optimal timing for surgery relative to immunotherapy.

摘要

转移性肾细胞癌的预后不佳，治疗选择有限。辅助性根治性肾切除术，可在全身免疫治疗之前或之后进行，已被提议作为改善治疗结果的一种方法。肾切除术对转移性疾病患者的作用仍存在争议。本文综述了肾切除术在转移性肾细胞癌中的作用以及相对于免疫治疗的最佳手术时机。