大鼠中枢神经系统中桃花心木/吸引素mRNA的分布。

Distribution of Mahogany/Attractin mRNA in the rat central nervous system.

作者信息

Lu X y, Gunn T M, Shieh K r, Barsh G S, Akil H, Watson S J

机构信息

University of Michigan School of Medicine, Mental Health Research Institute, 205 Zina Pitcher Place, Ann Arbor, MI 48109-0720, USA.

出版信息

FEBS Lett. 1999 Nov 26;462(1-2):101-7. doi: 10.1016/s0014-5793(99)01494-5.

DOI:10.1016/s0014-5793(99)01494-5

PMID:10580100

Abstract

The Mahogany/Attractin gene (Atrn) has been proposed as a downstream mediator of Agouti signaling because yellow hair color and obesity in lethal yellow (A(y)) mice are suppressed by the mahogany (Atrn(mg)) mutation. The present study examined the distribution of Atrn mRNA in the brain and spinal cord by in situ hybridization. Atrn mRNA was found widely distributed throughout the central nervous system, with high levels in regions of the olfactory system, some limbic structures, regions of the brainstem, cerebellum and spinal cord. In the hypothalamus, Atrn mRNA was found in specific nuclei including the suprachiasmatic nucleus, the supraoptic nucleus, the medial preoptic nucleus, the paraventricular hypothalamic nucleus, the ventromedial hypothalamic nucleus, and the arcuate nucleus. These results suggest a broad spectrum of physiological functions for the Atrn gene product.

摘要

由于桃花心木（Atrn）突变可抑制致死性黄色（A(y)）小鼠的黄毛和肥胖，因此桃花心木/吸引素基因（Atrn）被认为是刺豚鼠信号的下游介质。本研究通过原位杂交检测了Atrn mRNA在脑和脊髓中的分布。发现Atrn mRNA广泛分布于整个中枢神经系统，在嗅觉系统区域、一些边缘结构、脑干区域、小脑和脊髓中含量较高。在下丘脑，Atrn mRNA存在于特定核团中，包括视交叉上核、视上核、内侧视前核、下丘脑室旁核、下丘脑腹内侧核和弓状核。这些结果表明Atrn基因产物具有广泛的生理功能。