人类背根神经节神经元中的两种河豚毒素抗性钠通道。

Two tetrodotoxin-resistant sodium channels in human dorsal root ganglion neurons.

作者信息

Dib-Hajj S D, Tyrrell L, Cummins T R, Black J A, Wood P M, Waxman S G

机构信息

Department of Neurology LCI 707, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA.

出版信息

FEBS Lett. 1999 Nov 26;462(1-2):117-20. doi: 10.1016/s0014-5793(99)01519-7.

DOI:10.1016/s0014-5793(99)01519-7

PMID:10580103

Abstract

Two tetrodotoxin-resistant (TTX-R) voltage-gated sodium channels, SNS and NaN, are preferentially expressed in small dorsal root ganglia (DRG) and trigeminal ganglia neurons, most of which are nociceptive, of rat and mouse. We report here the sequence of NaN from human DRG, and demonstrate the presence of two TTX-R currents in human DRG neurons. One current has physiological properties similar to those reported for SNS, while the other displays hyperpolarized voltage-dependence and persistent kinetics; a similar TTX-R current was recently identified in DRG neurons of sns-null mouse. Thus SNS and NaN channels appear to produce different currents in human DRG neurons.

摘要

两种抗河豚毒素（TTX-R）电压门控钠通道，即SNS和NaN，优先在大鼠和小鼠的小型背根神经节（DRG）以及三叉神经节神经元中表达，其中大多数是伤害感受性神经元。我们在此报告了来自人类DRG的NaN序列，并证明了人类DRG神经元中存在两种TTX-R电流。一种电流具有与报道的SNS相似的生理特性，而另一种则表现出超极化电压依赖性和持续动力学；最近在sns基因敲除小鼠的DRG神经元中鉴定出了类似的TTX-R电流。因此，SNS和NaN通道似乎在人类DRG神经元中产生不同的电流。