Department of Gastroenterology, Henan Provincial People's Hospital, Zhengzhou University People's Hospital, Zhengzhou, China.
Department of Gastroenterology, The Second Xiangya Hospital, Central South University, Changsha, China.
Channels (Austin). 2023 Dec;17(1):2212350. doi: 10.1080/19336950.2023.2212350.
The Nav1.9 channel is a voltage-gated sodium channel. It plays a vital role in the generation of pain and the formation of neuronal hyperexcitability after inflammation. It is highly expressed in small diameter neurons of dorsal root ganglions and Dogiel II neurons in enteric nervous system. The small diameter neurons in dorsal root ganglions are the primary sensory neurons of pain conduction. Nav1.9 channels also participate in regulating intestinal motility. Functional enhancements of Nav1.9 channels to a certain extent lead to hyperexcitability of small diameter dorsal root ganglion neurons. The hyperexcitability of the neurons can cause visceral hyperalgesia. Intestinofugal afferent neurons and intrinsic primary afferent neurons in enteric nervous system belong to Dogiel type II neurons. Their excitability can also be regulated by Nav1.9 channels. The hyperexcitability of intestinofugal afferent neurons abnormally activate entero-enteric inhibitory reflexes. The hyperexcitability of intrinsic primary afferent neurons disturb peristaltic waves by abnormally activating peristaltic reflexes. This review discusses the role of Nav1.9 channels in intestinal hyperpathia and dysmotility.
Nav1.9 通道是一种电压门控钠离子通道。它在炎症后疼痛的产生和神经元兴奋性增高的形成中起着至关重要的作用。它在背根神经节的小直径神经元和肠神经系统中的 Dogiel II 神经元中高度表达。背根神经节的小直径神经元是疼痛传导的主要感觉神经元。Nav1.9 通道也参与调节肠道运动。Nav1.9 通道的功能增强在一定程度上导致小直径背根神经节神经元的兴奋性增高。神经元的兴奋性增高可导致内脏痛觉过敏。肠传出神经元和肠神经系统中的内在初级传入神经元属于 Dogiel Ⅱ型神经元。它们的兴奋性也可以被 Nav1.9 通道调节。肠传出神经元的兴奋性增高异常激活肠-肠抑制反射。内在初级传入神经元的兴奋性增高通过异常激活蠕动反射扰乱蠕动波。本文综述了 Nav1.9 通道在肠道高敏性和运动障碍中的作用。
