Quigley E M
Department of Medicine, National University of Ireland, Cork, Cork University Hospital, Ireland.
Baillieres Best Pract Res Clin Gastroenterol. 1999 Oct;13(3):385-95. doi: 10.1053/bega.1999.0034.
Recently, the small intestine has become the focus of investigation as a potential site of dysmotility in the irritable bowel syndrome (IBS). A number of motor abnormalities have been defined in some studies, and include 'clustered' contractions, exaggerated post-prandial motor response and disturbances in intestinal transit. The significance of these findings remains unclear. The interpretation of available studies is complicated by differences in subject selection, the direct influence of certain symptoms, such as diarrhoea and constipation, and the interference of compounding factors, such as stress and psychopathology. Dysmotility could also reflect autonomic dysfunction, disturbed CNS control and the response to heightened visceral sensation or central perception. While motor abnormalities may not explain all symptoms in IBS, sensorimotor interactions may be important in symptom pathogenesis and deserve further study.
最近，小肠已成为研究的焦点，被视为肠易激综合征（IBS）中潜在的动力障碍部位。一些研究已经明确了多种运动异常，包括“成簇”收缩、餐后运动反应过度以及肠道转运紊乱。这些发现的意义仍不明确。现有研究的解读因受试者选择的差异、某些症状（如腹泻和便秘）的直接影响以及复合因素（如压力和精神病理学）的干扰而变得复杂。动力障碍也可能反映自主神经功能障碍、中枢神经系统控制紊乱以及对内脏感觉增强或中枢感知的反应。虽然运动异常可能无法解释IBS的所有症状，但感觉运动相互作用在症状发病机制中可能很重要，值得进一步研究。
