Kellow J E, Bennett E
Department of Medicine, Royal North Shore Hospital, Sydney, Australia.
Semin Gastrointest Dis. 1996 Oct;7(4):208-16.
Sensorimotor disturbances of the small bowel are implicated increasingly in the pathogenesis of the functional gastrointestinal disorders. In irritable bowel syndrome (IBS), alterations in both interdigestive and postprandial motility have been described, for example, the specific peristaltic contractions that are normally present in the ileum appear to occur more frequently and to be associated with abdominal pain in some patients. The latter finding is likely to be related to the selective mechanoreceptor hypersensitivity that has been demonstrated in the small bowel of IBS patients. The level of this afferent dysfunction has, however, not been established; some evidence suggests that personality traits, which predispose to a more severe and prolonged sympathetic response to stressors, may hasten the development of such sensorimotor disturbances.
小肠的感觉运动障碍在功能性胃肠疾病的发病机制中所起的作用越来越受到关注。在肠易激综合征（IBS）中，已观察到消化间期和餐后运动的改变，例如，正常情况下在回肠出现的特定蠕动收缩在一些患者中似乎更频繁地发生，并且与腹痛相关。后一发现可能与IBS患者小肠中已证实的选择性机械感受器超敏反应有关。然而，这种传入功能障碍的程度尚未确定；一些证据表明，易对压力源产生更严重和持久交感反应的人格特质可能会加速这种感觉运动障碍的发展。
