[各种麻黄碱异构体对离体灌注兔心脏去甲肾上腺素摄取的构效关系]

[Structure-activity relationship of various ephedrine isomers on noradrenaline uptake by the isolated perfused rabbit heart].

作者信息

Chanh P H, Chanh A P, Azum-Gelade M C, Taudou A, van Thoai M N

出版信息

C R Acad Hebd Seances Acad Sci D. 1978 Nov 13;287(13):1259-62.

Abstract

(-)Ephedrine, (+) Ephedrine, (-) psi ephedrine and (+) psi ephedrine inhibit both the neuronal and extraneuronal uptakes of noradrenaline in isolated Rabbit heart. (-) ephedrine is the most active isomer for the inhibition of both neuronal and extraneuronal uptakes. The relative inhibition potential of the three other isomers is not the same when applied to one or other uptake.

摘要

（-）麻黄碱、（+）麻黄碱、（-）假麻黄碱和（+）假麻黄碱均抑制离体兔心脏中去甲肾上腺素的神经元摄取和非神经元摄取。（-）麻黄碱是抑制神经元摄取和非神经元摄取最具活性的异构体。当应用于一种或另一种摄取时，其他三种异构体的相对抑制潜力并不相同。