Wooley J C
University of California San Diego, La Jolla 92093-0505, USA.
J Comput Biol. 1999 Fall-Winter;6(3-4):459-74. doi: 10.1089/106652799318391.
Computational biology, a term coined from analogy to the role of computing in the physical sciences, is now coming into its own as a major element of contemporary biological and biomedical research. Information science and computational science provide essential tools for next generation biological science efforts, from focusing the direction of experimental studies to providing knowledge and insight that can not otherwise be obtained. Going beyond the revolution in biology reflected in the successes of the genome project and driven by the power of molecular biology techniques, computational approaches will provide an underpinning for the integration of broad disciplines for development of a quantitative systems approach to understanding the mechanisms in the life of the cell.
计算生物学这一术语源于类比计算在物理科学中的作用，如今正作为当代生物学和生物医学研究的一个主要元素崭露头角。信息科学和计算科学为下一代生物学研究提供了至关重要的工具，从聚焦实验研究方向到提供通过其他方式无法获得的知识和见解。超越基因组计划成功所反映的生物学革命，并受分子生物学技术力量的推动，计算方法将为整合多学科以发展定量系统方法来理解细胞生命机制提供支撑。
