Alonso P
Chemotherapy. 1979;25(1):40-7. doi: 10.1159/000237820.
The effect of tinidazole on several ciliates (Stylonychia muscorum, Stylonychia mytilus, Tetrahymena pyriformis, Vorticella companula) has been studied. There is a very pronounced difference in sensitivity against this drug between the free-living ciliates here investigated and certain parasitic protozoa. A high resistance of the free-living ciliates against tinidazole, probably due to their aerobic condition, has been found. Nonetheless, tinidazole at high doses (1--3 mg/ml) caused severe alterations in 3 of the 4 aerobic ciliate species here studied.
研究了替硝唑对几种纤毛虫（苔藓柱虫、贻贝柱虫、梨形四膜虫、钟形钟虫）的作用。在所研究的自由生活纤毛虫与某些寄生原生动物之间，对这种药物的敏感性存在非常明显的差异。已发现自由生活纤毛虫对替硝唑具有高度抗性，这可能归因于它们的需氧状态。尽管如此，高剂量（1 - 3毫克/毫升）的替硝唑对这里研究的4种需氧纤毛虫中的3种造成了严重改变。
