Weisshaar E, Schramm M, Gollnick H
Department of Dermatology and Venereology, Otto-von-Guericke-University, Leipzigerstrasse 44, 39120 Magdeburg, Germany.
Eur J Dermatol. 1999 Dec;9(8):621-3.
Familial sebaceous gland hyperplasia is a benign entity with onset at puberty and a tendency to worsen with age. It is characterized by a nevoid symmetric pattern in the sebaceous areas of the face sparing the orbital, perinasal, preauricular and perioral areas showing prominent follicular openings and interfollicular dermal yellowish or white prominent skin. Usually, the face is affected, with the neck, column and thorax affected in a milder pattern. We describe a family with familial nevoid sebaceous gland hyperplasia in three consecutive generations. All the patients were successfully treated with oral isotretinoin. The pedigree suggests autosomal dominant inheritance with incomplete penetrance.
家族性皮脂腺增生是一种良性疾病，于青春期发病，且有随年龄增长而加重的趋势。其特征为在面部皮脂腺区域呈痣样对称分布，不累及眶周、鼻周、耳前及口周区域，表现为明显的毛囊开口以及毛囊间皮肤呈黄色或白色突出。通常面部受累，颈部、躯干和胸部受累程度较轻。我们描述了一个连续三代患有家族性痣样皮脂腺增生的家族。所有患者均通过口服异维A酸成功治疗。该系谱提示为常染色体显性遗传，具有不完全外显率。
